Graphical representation of the molecular relationships among the candidate CRC biomarkers identified in human plasma; CEA, TFRC, MIF and OPN/SPP1. The top associated network was the Organ Morphology, Cardiovascular Disease, Cellular Development network. Molecule types have their background highlighted as described in the blue box. Edges with dashed lines show indirect interaction, while an unbroken line represents direct interactions. Molecules in uncolored notes were integrated into the computationally generated networks on the basis of the evidence stored in the IPA knowledge memory indicating a relevance to this network.