The activation of Notch signaling in langendorff-perfused isolated heart. A, N1ICD level was upregulated in IPC and IPost. B, Hes1 level was regulated by I/R, IPC and IPost with or without LV-N1ICD/LV-N1ICD-shRNA infection. C, The phosphorylation of Stat3 in different groups of myocardium. Data were presented as mean ± SD, n=3. Mock1 indicated the hearts infected with empty vector, Mock2 indicated the hearts infected with vector containing nonspecfic sequences. ▲P>0.05, *P<0.05, **P<0.01.