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Table 1 Examples of effect formulas

From: Effective visualization of integrated knowledge and data to enable informed decisions in drug development and translational medicine

Effect formula Effect definition Unit of reference value
m Unscaled (e.g. occupancy, %) %
m - mbl Change from baseline (raw) Same unit as endpoint
m - mctrl Change from control (raw) Same unit as endpoint
100*((m -mbl) / mbl) Change from baseline (%) %
100*((m - mctrl) / (mctrl) Change from control (%) %
100*(Nsbj,grp/Ngrp – Nsbj,ctrl /Nctrl) Diff in % Event (percentage points) % (percentage points)
  1. M; mean response of endpoint at the corresponding exposure level.
  2. mbl; mean response of endpoint at the baseline.
  3. mctrl; mean response of endpoint at the corresponding exposure level in the control group.
  4. Ngrp; total number of subjects in the group.
  5. Nsbj,grp; number of subjects that experienced the event in the group.
  6. Nctrl; number of subjects in the control group.
  7. Nsbj,ctrl; number of subjects that experienced the event in the control group.