Relationship in the knowledge plot between drug candidate and internal or external comparators with focus on adverse event in single and multiple dose studies: comparison of adverse event frequencies (red triangles) between compound A and B, including data from both single and multiple ascending dose studies. The adverse event profiles are similar regardless of treatment duration time for the two compounds, respectively. However, there is a difference between compound A and B, where the former demonstrate a less favorable safety profile. By including target engagement c.f. Figure 4, there is a possibility to illustrate target related safety. Legends for species: rat (star), monkey (circle), human (triangle).