Figure 2

Traditional visualizations compared to the knowledge plot. The left part demonstrate a mixture of scatter, bar and line plots combined with tables. The right part illustrates the Knowledge Plot concentration-response profiles by using Treatment Effect Index on the vertical axis and the unbound concentration on the horizontal axis. Safety endpoints are colored by red and efficacy endpoints are blue to visualize the therapeutic window, which is the difference in exposure between the blue efficacy endpoint and the red safety endpoint on the horizontal 100-line. In addition, one point estimate representing a Ki value and a concentration range (no observed adverse effect level (NOAEL) and the lowest observed adverse effect level (LOAEL)) are shown in the lower part of the graph.