Figure 2

Kaplan-Meier survival curves of patients who were alive after the CHP-NY-ESO-1 vaccinations. A: Progression-free survival (PFS) of patients assigned to Cohort 1 (100-μg dose, n = 13) or Cohort 2 (200-μg dose, n = 12). The probability of PFS of the patients who received 200 μg of the vaccine and those who received the 100-μg dose were similar (log-rank test, p = 0.748). B: Overall survival (OS) of patients assigned to Cohort 1 or Cohort 2. The patients who received 200 μg of the vaccine survived longer than those who received the 100-μg dose. (log-rank test, p = 0.050). C: OS of patients vaccinated with either 100 μg or 200 μg of CHP-NY-ESO-1 compared between patients who responded to previous therapies and those who never responded. The patients who responded to previous therapies and were vaccinated with CHP-NY-ESO-1 survived longer than non-responders. (log-rank test, p = 0.0050). D: OS of patients vaccinated with 100 μg or 200 μg of CHP-NY-ESO-1 who never responded to previous therapies. The patients who received 200 μg of the vaccine survived longer than those who received the 100-μg dose (log-rank test, p = 0.029). E: OS of patients vaccinated with 100 μg or 200 μg of CHP-NY-ESO-1 compared with either baseline tumor burdens of >30 mm (sum of the tumor diameters) or 30 mm or less including non-measurable lesions. The patients with a tumor burden higher than 30 mm had reduced survival compared to those with smaller burdens (log-rank test, p = 0.021). F: OS of patients who received 100 μg or 200 μg of CHP-NY-ESO-1 who had baseline tumor burdens greater than 30 mm. The patients who received 200 μg of the vaccine survived longer than those who received the 100-μg dose (log-rank test, p = 0.037).