Table 5 Functional properties of salivary proteins found differentially expressed between CFS patient and his healthy twin
n° | Protein name | Functional properties |
|---|---|---|
Immune system | ||
1509 | cyclophilin A | Protein with peptidyl-prolyl cis-trans isomerase activity, which accelerates the folding of proteins and catalyzes conformational changes in several cellular processes. |
815 | Ig alpha-1 chain C region | Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. |
91 | Polymeric immunoglobulin receptor | This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment |
Inflammatory response | ||
1621 | Protein S100-A7 | It has been associated with increased inflammatory cell infiltrates in breast cancer and various inflammatory disorders, and recently its role in the production of pro-inflammatory molecules has been demonstrated on breast tumor cells. |
1575 | Cystatin-C | Proteins with a role in protein catabolism, in regulation of hormone processing and bone resorption, in inflammation, in antigen presentation and T-cell dependent immune response as well as resistance to various bacterial and viral infections. |
1620 | Cystatin-B | Cystatin-B is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. |
Signal transduction | ||
1051 | 14-3-3 protein zeta/delta | Phosphoserine/phosphothreonine-recognition proteins implicated in the regulation of many intracellular signaling. 14-3-3 proteins form homo- or hetero dimers and they can bind different molecules (e.g. kinases, phosphatases, transmembrane receptors and transcription factors). |
Metabolism | ||
1736 | Zinc-alpha-2-glycoprotein (ZAG) | It is mainly known as an adipokine responsible for lipid degradation that causes loss of adipose tissue in cancer cachexia. Beyond this action, a role of ZAG in the activation of AMP kinase, an important regulator of energy metabolism, in human skeletalmuscle cells has emerged. |