Table 4 The mRNA expression of PPAR and fibrosis-related genes in ACE2 deficient hearts after irbesartan treatment (n = 3)
Gene name | Description | Folds up- or down-regulation (Vs. ACE2KO mice) | P value |
|---|---|---|---|
PPARα | peroxisome proliferator activated receptor-α | 1.46 | 0.655 |
PPARδ | peroxisome proliferator activated receptor-δ | −1.04 | 0.456 |
PPARγ | peroxisome proliferator activated receptor-γ | 3.26 | 0.010 |
CTGF | connective tissue growth factor | −3.03 | 0.019 |
Col3A1 | collagen, type III, alpha 1 | −2.05 | 0.013 |
FN1 | fibronectin | −1.55 | 0.107 |
TGF-β1 | transforming growth factor-β1 | −2.55 | 0.008 |
TGF-β2 | transforming growth factor-β2 | −1.24 | 0.789 |