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Table 4 The mRNA expression of PPAR and fibrosis-related genes in ACE2 deficient hearts after irbesartan treatment (n = 3)

From: Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice

Gene name Description Folds up- or down-regulation (Vs. ACE2KO mice) P value
PPARα peroxisome proliferator activated receptor-α 1.46 0.655
PPARδ peroxisome proliferator activated receptor-δ −1.04 0.456
PPARγ peroxisome proliferator activated receptor-γ 3.26 0.010
CTGF connective tissue growth factor −3.03 0.019
Col3A1 collagen, type III, alpha 1 −2.05 0.013
FN1 fibronectin −1.55 0.107
TGF-β1 transforming growth factor-β1 −2.55 0.008
TGF-β2 transforming growth factor-β2 −1.24 0.789