Table 3 Summary of genotypes-phenotypes for NOS1 SNPs that were classified based on Tmax values in all children
Number of significant SNPs | SNP | Allele frequencies | ||||
|---|---|---|---|---|---|---|
1 | rs6490121 | *AA | GA | *GG | *AA + GA | GG + GA |
(A/G) | (n = 51) | (n = 50) | (n = 21) | (n = 101) | (n = 71) | |
Tmax | *39.23 ± 22.10 | 39.99 ± 21.14 | *31.55 ± 13.57 | 39.60 ± 21.53 | 37.49 ± 19.51 | |
2 | rs2293052 | CC | TC | TT | CC + TC | TT + TC |
(C/T) | (n = 69) | (n = 39) | (n = 14) | (n = 108) | (n = 53) | |
Tmax | 36.50 ± 19.02 | 42.13 ± 23.15 | 35.80 ± 20.22 | 38.53 ± 20.68 | 40.45 ± 22.40 | |
3 | rs3825102 | AA | AC | CC | AA + AC | CC + AC |
(A/C) | (n = 13) | (n = 45) | (n = 64) | (n = 58) | (n = 109) | |
Tmax | 35.02 ± 20.82 | 43.95 ± 24.46 | 34.84 ± 16.56 | 41.95 ± 23.82 | 38.60 ± 20.59 | |
4 | rs4767529 | CC | GC | GG | CC + GC | GG + GC |
(C/G) | (n = 56) | (n = 51) | (n = 15) | (n = 107) | (n = 66) | |
Tmax | 35.66 ± 16.94 | 41.43 ± 24.04 | 36.84 ± 19.90 | 38.41 ± 20.74 | 40.39 ± 23.10 | |
5 | rs561712 | AA | AG | GG | AA + AG | GG + AG |
(A/G) | (n = 17) | (n = 53) | (n = 52) | (n = 70) | (n = 105) | |
Tmax | 35.26 ± 19.75 | 41.67 ± 23.43 | 35.66 ± 17.29 | 40.12 ± 22.62 | 38.70 ± 20.74 | |
6 | rs549098 | CC | TC | TT | CC + TC | TT + TC |
(C/T) | (n = 54) | (n = 50) | (n = 18) | (n = 104) | (n = 68) | |
Tmax | 35.21 ± 16.44 | 42.04 ± 24.54 | 36.61 ± 18.86 | 38.50 ± 20.91 | 40.60 ± 23.16 | |
7 | rs567581 | AA | AG | GG | AA + AG | GG + AG |
(A/G) | (n = 18) | (n = 49) | (n = 55) | (n = 67) | (n = 104) | |
Tmax | 36.61 ± 18.86 | 42.26 ± 24.75 | 35.14 ± 16.30 | 40.74 ± 23.31 | 38.50 ± 20.91 | |
8 | rs483589 | *AA | AG | *GG | *AA + AG | GG + AG |
(A/G) | (n = 22) | (n = 51) | (n = 49) | (n = 73) | (n = 100) | |
Tmax | *42.88 ± 19.56 | 41.56 ± 23.18 | *32.65 ± 16.88 | *41.96 ± 22.02 | 37.19 ± 20.73 | |
9 | rs693534 | AA | AG | GG | AA + AG | GG + AG |
(A/G) | (n = 24) | (n = 47) | (n = 51) | (n = 71) | (n = 98) | |
Tmax | 43.82 ± 19.41 | 38.19 ± 20.74 | 35.61 ± 20.79 | 40.09 ± 20.34 | 36.85 ± 20.70 | |
10 | rs9658255 | CC | GC | GG | CC + GC | GG + GC |
(C/G) | (n = 51) | (n = 49) | (n = 22) | (n = 100) | (n = 71) | |
Tmax | 35.22 ± 20.80 | 39.53 ± 20.53 | 42.24 ± 19.98 | 37.33 ± 20.68 | 40.37 ± 20.26 | |
11 | rs1879417 | *CC | CT | *TT | CC + CT | *TT + CT |
(C/T) | (n = 28) | (n = 55) | (n = 39) | (n = 83) | (n = 94) | |
|  | Tmax | *45.55 ± 19.68 | 37.33 ± 21.45 | *34.21 ± 18.97 | 40.10 ± 21.11 | *36.03 ± 20.41 |