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Table 3 Summary of genotypes-phenotypes for NOS1 SNPs that were classified based on Tmax values in all children

From: Genetic variance in Nitric Oxide Synthase and Endothelin Genes among children with and without Endothelial Dysfunction

Number of significant SNPs SNP Allele frequencies
1 rs6490121 *AA GA *GG *AA + GA GG + GA
(A/G) (n = 51) (n = 50) (n = 21) (n = 101) (n = 71)
Tmax *39.23 ± 22.10 39.99 ± 21.14 *31.55 ± 13.57 39.60 ± 21.53 37.49 ± 19.51
2 rs2293052 CC TC TT CC + TC TT + TC
(C/T) (n = 69) (n = 39) (n = 14) (n = 108) (n = 53)
Tmax 36.50 ± 19.02 42.13 ± 23.15 35.80 ± 20.22 38.53 ± 20.68 40.45 ± 22.40
3 rs3825102 AA AC CC AA + AC CC + AC
(A/C) (n = 13) (n = 45) (n = 64) (n = 58) (n = 109)
Tmax 35.02 ± 20.82 43.95 ± 24.46 34.84 ± 16.56 41.95 ± 23.82 38.60 ± 20.59
4 rs4767529 CC GC GG CC + GC GG + GC
(C/G) (n = 56) (n = 51) (n = 15) (n = 107) (n = 66)
Tmax 35.66 ± 16.94 41.43 ± 24.04 36.84 ± 19.90 38.41 ± 20.74 40.39 ± 23.10
5 rs561712 AA AG GG AA + AG GG + AG
(A/G) (n = 17) (n = 53) (n = 52) (n = 70) (n = 105)
Tmax 35.26 ± 19.75 41.67 ± 23.43 35.66 ± 17.29 40.12 ± 22.62 38.70 ± 20.74
6 rs549098 CC TC TT CC + TC TT + TC
(C/T) (n = 54) (n = 50) (n = 18) (n = 104) (n = 68)
Tmax 35.21 ± 16.44 42.04 ± 24.54 36.61 ± 18.86 38.50 ± 20.91 40.60 ± 23.16
7 rs567581 AA AG GG AA + AG GG + AG
(A/G) (n = 18) (n = 49) (n = 55) (n = 67) (n = 104)
Tmax 36.61 ± 18.86 42.26 ± 24.75 35.14 ± 16.30 40.74 ± 23.31 38.50 ± 20.91
8 rs483589 *AA AG *GG *AA + AG GG + AG
(A/G) (n = 22) (n = 51) (n = 49) (n = 73) (n = 100)
Tmax *42.88 ± 19.56 41.56 ± 23.18 *32.65 ± 16.88 *41.96 ± 22.02 37.19 ± 20.73
9 rs693534 AA AG GG AA + AG GG + AG
(A/G) (n = 24) (n = 47) (n = 51) (n = 71) (n = 98)
Tmax 43.82 ± 19.41 38.19 ± 20.74 35.61 ± 20.79 40.09 ± 20.34 36.85 ± 20.70
10 rs9658255 CC GC GG CC + GC GG + GC
(C/G) (n = 51) (n = 49) (n = 22) (n = 100) (n = 71)
Tmax 35.22 ± 20.80 39.53 ± 20.53 42.24 ± 19.98 37.33 ± 20.68 40.37 ± 20.26
11 rs1879417 *CC CT *TT CC + CT *TT + CT
(C/T) (n = 28) (n = 55) (n = 39) (n = 83) (n = 94)
  Tmax *45.55 ± 19.68 37.33 ± 21.45 *34.21 ± 18.97 40.10 ± 21.11 *36.03 ± 20.41
  1. *Indicates significant alleles.