Figure 4

Correlations between HMGB1, TLR3, TLR7, TRIF, PKR, caspase-3, inflammation, apoptosis, renal function and structure. The positive correlations were revealed between HMGB1 protein and MPO+ cells (A), TID score, ISEL+ cells (B), 17 kD caspase-3 (C) and TLR3 (D). The negative correlation was revealed between HMGB1 and 32 kD caspase-3 (C). TLR3 (E), TLR7 (F) and PKR (G) were also correlated with IFN-α, IFN-β and IFN-γ respectively. In addition, there were positive correlations between serum creatinine and TRIF or MyD88 (H).