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Table 1 Correlation of ETAR/CXCR4 expression with prognostic factors in patients with nasopharyngeal carcinoma

From: The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways

  Entire group CXCR4 expression ETAR expression
  (n = 153) n (No.%) n (No.%)
Characteristic   Positive Negative P value Positive Negative P value
All patients 153 48(31.4) 105(68.6)   113(73.9) 40(26.1)  
Mean follow-up, months 83.27 62.77 92.64   79.81 93.05  
Age, years     0.049    0.741
≤50 100(65.4) 26(26.0) 74(74.0)   73(73.0) 27(27.0)  
>50 53(34.6) 22(41.6) 31(58.4)   40(75.5) 13(24.5)  
Sex     0.27    0.213
Male 111(72.5) 32(28.8) 79(71.2)   85(76.6) 26(23.4)  
Female 42(27.5) 16(38.1) 26(61.9)   28(66.7) 14(33.3)  
T classification a     0.098    0.517
T1-2 66(43.1) 16(24.2) 50(75.8)   47(71.2) 19(28.8)  
T3-4 87(56.9) 32(36.8) 55(63.2)   66(75.9) 21(24.1)  
N classification a     0.681    0.284
N0 32(20.9) 11(34.4) 21(65.6)   26(81.3) 6(19.7)  
N1-N3 121(79.1) 37(30.6) 84(69.4)   87(71.9) 34(29.1)  
Overall stage a     0.376    0.94
I-II 49(32.0) 13(26.5) 36(73.5)   36(73.5) 13(26.5)  
III-IV 104(68.0) 35(33.7) 69(66.3)   77(74.0) 27(26.0)  
Chemotherapy     0.394    0.362
Yes 47(30.7) 17(36.2) 30(63.8)   37(78.7) 10(21.3)  
No 106(69.3) 31(29.2) 75(70.8)   76(71.7) 30(28.3)  
  1. Note: All patients were classified with World Health Organization (WHO) type III NPC.
  2. aUICC 1997 staging system.