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Table 1 Correlation of ETAR/CXCR4 expression with prognostic factors in patients with nasopharyngeal carcinoma

From: The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways

 

Entire group

CXCR4 expression

ETAR expression

 

(n = 153)

n (No.%)

n (No.%)

Characteristic

 

Positive

Negative

P value

Positive

Negative

P value

All patients

153

48(31.4)

105(68.6)

 

113(73.9)

40(26.1)

 

Mean follow-up, months

83.27

62.77

92.64

 

79.81

93.05

 

Age, years

   

0.049

  

0.741

≤50

100(65.4)

26(26.0)

74(74.0)

 

73(73.0)

27(27.0)

 

>50

53(34.6)

22(41.6)

31(58.4)

 

40(75.5)

13(24.5)

 

Sex

   

0.27

  

0.213

Male

111(72.5)

32(28.8)

79(71.2)

 

85(76.6)

26(23.4)

 

Female

42(27.5)

16(38.1)

26(61.9)

 

28(66.7)

14(33.3)

 

T classification a

   

0.098

  

0.517

T1-2

66(43.1)

16(24.2)

50(75.8)

 

47(71.2)

19(28.8)

 

T3-4

87(56.9)

32(36.8)

55(63.2)

 

66(75.9)

21(24.1)

 

N classification a

   

0.681

  

0.284

N0

32(20.9)

11(34.4)

21(65.6)

 

26(81.3)

6(19.7)

 

N1-N3

121(79.1)

37(30.6)

84(69.4)

 

87(71.9)

34(29.1)

 

Overall stage a

   

0.376

  

0.94

I-II

49(32.0)

13(26.5)

36(73.5)

 

36(73.5)

13(26.5)

 

III-IV

104(68.0)

35(33.7)

69(66.3)

 

77(74.0)

27(26.0)

 

Chemotherapy

   

0.394

  

0.362

Yes

47(30.7)

17(36.2)

30(63.8)

 

37(78.7)

10(21.3)

 

No

106(69.3)

31(29.2)

75(70.8)

 

76(71.7)

30(28.3)

 
  1. Note: All patients were classified with World Health Organization (WHO) type III NPC.
  2. aUICC 1997 staging system.
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Journal of Translational Medicine

ISSN: 1479-5876

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