Table 4 Contribution of individual TNF-α and LT-α gene polymorphisms in CF associated liver disease
From: TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression
TNF genes | Cirrhosis (total) | p* | p** | Cirrhosis (without PH) | p* | p** |
|---|---|---|---|---|---|---|
TNF-α-308GA–LT-α + 252AA | 1/13 (7.7%) | 0.061 | 0.018 | 0/13 | 0.028 | 0.016 |
TNF-α-308 G–LT- + 252AA | 31/97 (32%) | — | >0.1 | 25/97 (25.8%) | — | >0.1 |
TNF-α-308GA–LT- + 252AG | 13/29 (44.8%) | >0.1 | — | 9/29 (31.0%) | >0.1 | — |
TNF-α-308GG–LT- + 252AG | 5/37 (13.5%) | 0.023 | 0.005 | 4/37 (10.8%) | 0.045 | 0.041 |
TNF-α-308GG–LT- + 252GG together with | 2/12 (16.7%) | >0.1 | 0.087 | 0/12 | 0.036 | 0.029 |
TNF-α-308GA–LT- + 252GG |