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Table 4 Contribution of individual TNF-α and LT-α gene polymorphisms in CF associated liver disease

From: TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression

TNF genes Cirrhosis (total) p* p** Cirrhosis (without PH) p* p**
TNF-α-308GALT-α + 252AA 1/13 (7.7%) 0.061 0.018 0/13 0.028 0.016
TNF-α-308 GLT- + 252AA 31/97 (32%) >0.1 25/97 (25.8%) >0.1
TNF-α-308GALT- + 252AG 13/29 (44.8%) >0.1 9/29 (31.0%) >0.1
TNF-α-308GGLT- + 252AG 5/37 (13.5%) 0.023 0.005 4/37 (10.8%) 0.045 0.041
TNF-α-308GGLT- + 252GG together with 2/12 (16.7%) >0.1 0.087 0/12 0.036 0.029
TNF-α-308GALT- + 252GG       
  1. Boldface shows the unfavorable genotype in term of CF associated liver disease progression.
  2. PH, portal hypertension.
  3. * comparison with TNF-α-308GGLT-α + 252AA.
  4. ** comparison with TNF-α-308GALT-α + 252AG.