Table 3 Frequencies of concomitant diseases in CF patients with different TNF-α and LT-α gene polymorphisms
From: TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression
Genotype | Asthma | Tuberculosis | Virus hepatitis |
|---|---|---|---|
TNF-α–308 GG | 5.8% | 5.0% | 6.3% |
(n = 145) | (8/145) | (7/140) | (8/143) |
TNF-α–308GA | 14.0% | 2.9% | 3.8% |
(n = 53) | (7/53) | (2/51) | (2/53) |
P-value | 0.068 | 0.94 | 0.9 |
LT-α + 252AA | 6.5% | 8.3% | 6.4% |
(n = 110) | (7/110) | (9/108) | (7/109) |
LT-α + 252GA | 7.8% | 0% | 0% |
(n = 67) | (5/67) | (0/65) | (0/65) |
LT-α + 252GG | 10.0% | 0% | 16.7% |
(n = 12) | (1/12) | (0/11) | (1/12) |
P value | PA/A,G/A = 0.013 | PA/A,G/A = 0.035 | |
PA/A,G/G+G/A = 0.007 | PA/A,G/G+G/A = 0.088 |