Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry

Table 5 Cox proportional univariate and multivariate analyses of the association between prognostic variables and overall survival in cervical cancer

	Univariate analysis		Multivariate analysis based on HIF-1α^a		Multivariate analysis based on c-Met^a
	Hazard ratio [95% CI]	p value	Hazard ratio [95% CI]	p value	Hazard ratio[95% CI]	p value
FIGO stage (≥IIb)	2.60 [1.02-6.56]	0.043	1.03 [0.31-3.40]	0.951	0.96 [0.28-3.25]	0.951
Tumor grade (poor)	1.39 [0.55-3.51]	0.486	NA		NA
Tumor size (> 4 cm)	2.33 [0.91-5.94]	0.076	NA		NA
LVSI	2.81 [0.99-7.94]	0.050	0.91 [0.19-4.35]	0.915	0.79 [0.17-3.59]	0.768
LN metastasis	4.96 [1.75-13.99]	0.008	4.23 [0.84-21.34]	0.080	4.83 [1.09-21.42]	0.038
HIF-1α ^b	2.91 [1.09-7.78]	0.019	1.84 [0.54-6.30]	0.326	NA
c-Met ^c	1.96 [1.22-3.16]	0.005	NA		3.27 [1.05-10.23]	0.041

NA, not applicable; LVSI, lymphovascular space invasion; ^a Separate multivariate analysis for HIF-1α and c-MET was performed because both factors are dependent on each other, ^b Cut-off value of HIF-1α is 8 of IHC score, ^c Cut-off value of c-Met is 8 of IHC score.

ISSN: 1479-5876