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Table 5 Cox proportional univariate and multivariate analyses of the association between prognostic variables and overall survival in cervical cancer

From: Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry

  Univariate analysis Multivariate analysis based on HIF-1αa Multivariate analysis based on c-Meta
Hazard ratio [95% CI] p value Hazard ratio [95% CI] p value Hazard ratio[95% CI] p value
FIGO stage (≥IIb) 2.60 [1.02-6.56] 0.043 1.03 [0.31-3.40] 0.951 0.96 [0.28-3.25] 0.951
Tumor grade (poor) 1.39 [0.55-3.51] 0.486 NA   NA  
Tumor size (> 4 cm) 2.33 [0.91-5.94] 0.076 NA   NA  
LVSI 2.81 [0.99-7.94] 0.050 0.91 [0.19-4.35] 0.915 0.79 [0.17-3.59] 0.768
LN metastasis 4.96 [1.75-13.99] 0.008 4.23 [0.84-21.34] 0.080 4.83 [1.09-21.42] 0.038
HIF-1α b 2.91 [1.09-7.78] 0.019 1.84 [0.54-6.30] 0.326 NA  
c-Met c 1.96 [1.22-3.16] 0.005 NA   3.27 [1.05-10.23] 0.041
  1. NA, not applicable; LVSI, lymphovascular space invasion; a Separate multivariate analysis for HIF-1α and c-MET was performed because both factors are dependent on each other, b Cut-off value of HIF-1α is 8 of IHC score, c Cut-off value of c-Met is 8 of IHC score.