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Table 5 Drugs with serendipitous off-target effects on cognition and memory

From: A network model of genomic hormone interactions underlying dementia and its translational validation through serendipitous off-target effect

Drug name Main indication Positive side effect on cognition and memory Study subjects/design Supporting evidence (PMID) Target protein in core DHN
Bexarotene (Targretin) Skin cancer Rapid reversal of cognition, social and olfactory deficits Mouse model of AD 22323736 RXRA
RXRB
Tamoxifen Breast cancer Higher level of independence in activities of daily life and decision making; relationship of tamoxifen with a lower prevalence of AD Cross-sectional study of women receiving tamoxifen 11005221 ESR1
Raloxifene Breast cancer Reduced risk of cognitive impairment in postmenopausal women The Multiple Outcomes of Raloxifene Evaluation (MORE) randomized, placebo-controlled trial amonf postmenopausal women with osteoporosis 15800139 ESR1
Vorinostat Cutaneous T cell lymphoma (skin cancer) Complete restoration of contextual memory Mutant APPswe/PS1dE9 mice 20010553 HDAC2
HDAC3
Lovastatin Hyperlipidemia Reduction of Abeta formation and slowing the progression of AD Double-blind randomized study on human subjects 11900994 HDAC2
Resveratrol Aging Promoting clearance of Abeta peptides Various cell lines 16162502 CSNK2A1
Sorafenib Renal cell carcinoma Reversal of memory impairment Transgenic APPswe mouse model 20201822 BRAF
Naloxone Opioid overdose Improvement of learning and memory through enhancement of long-term potentiation Aged rats with declined memory 14670637 CREB1
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