Skip to main content

Table 2 List of dementia-related hormone signaling pathways that were recovered fully or partially in DHN

From: A network model of genomic hormone interactions underlying dementia and its translational validation through serendipitous off-target effect

Hormone signaling pathway No. of proteins in the gold-standard pathway No. of proteins present in the hormone-dementia network
Estrogen receptor pathway 30 25 (83% recovery)
Insulin signaling pathway 21 21 (100% recovery)
Growth hormone pathway 27 27 (100% recovery)
Leptin signaling pathway 21 17 (80% recovery)
Thyroid signaling pathway 11 8 (72% recovery)
Melatonin signaling pathway 16 16 (100% recovery)
Corticotropin-releasing hormone signaling pathway 17 16 (94% recovery)