Table 2 List of dementia-related hormone signaling pathways that were recovered fully or partially in DHN
Hormone signaling pathway | No. of proteins in the gold-standard pathway | No. of proteins present in the hormone-dementia network |
|---|---|---|
Estrogen receptor pathway | 30 | 25 (83% recovery) |
Insulin signaling pathway | 21 | 21 (100% recovery) |
Growth hormone pathway | 27 | 27 (100% recovery) |
Leptin signaling pathway | 21 | 17 (80% recovery) |
Thyroid signaling pathway | 11 | 8 (72% recovery) |
Melatonin signaling pathway | 16 | 16 (100% recovery) |
Corticotropin-releasing hormone signaling pathway | 17 | 16 (94% recovery) |