Analysis of combined MT2A with TNM stage to predict clinical outcome in GC. Kaplan–Meier analysis of overall-survival for MT2A expression was used according to TNM stage. A, Prognostic value of MT2A expression in GC patients was benefit for predicting the outcome of patients, low expression of MT2A was associated with poor overall survival (P < 0.01); B, TNM stage was benefit for the prognostic prediction in GC patients. C D, Prognostic value of MT2A in TNM stage I-II and stage III-IV (P = 0.048, P < 0.001, respectively); E F, Prognostic value of MT2A expression in lymph node metastasis or not (P < 0.001, P = 0.052, respectively); G. Prognostic value of MT2A expression in no distant metastasis subgroup (n = 232, P < 0.001); H. Prognostic value of MT2A in pT3-pT4 subgroup (P < 0.001). All data imply that MT2A could be an effective prognostic signature.