Table 4 Top 10 of the significant GeneGo pathways enriched with both DE-miRNA targets and RCC-related genes
Pathway map | Pathway map category | Ratio of RCC related objects | P-value | PubMed citation count |
|---|---|---|---|---|
TGF, WNT and cytoskeletal remodeling | Cytoskeleton remodeling | 25/111 | 2.41E-16 | Â |
AKT signaling | Signal transduction | 17/43 | 5.00E-16 | 70 |
Brca1 as a transcription regulator | DNA damage | 13/30 | 3.70E-13 | Â |
PTEN pathway | Signal transduction | 15/46 | 7.79E-13 | 22 |
PIP3 signaling in cardiac myocytes | Development | 15/47 | 1.12E-12 | Â |
Regulation of epithelial-to-mesenchymal transition (EMT) | Development | 16/64 | 1.12E-11 | 12 |
Influence of Ras and Rho proteins on G1/S Transition | Cell cycle | 14/53 | 1.14E-10 | 2 |
Cytoskeleton remodeling | Cytoskeleton remodeling | 18/102 | 3.30E-10 | 2 |
Regulation of G1/S transition (part 1) | Cell cycle | 11/38 | 7.43E-10 | 4 |
Receptor-mediated HIF regulation | Transcription | 11/39 | 1.02E-9 | 7 |