Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies

Table 3 Patient samples and corresponding patient-derived NSCLC xenograft model information

Model ID	Patient NSCLC tissue implanted					Patient derived LC xenograft models
	Pathology	Mutation detection		Gene amplification		Mutation detection		Gene amplification		% TGI
		EGFR	KRAS	FGFR1	MET	EGFR	KRAS	FGFR1	MET	by Gefitinib
L004	AC	WT	WT	None	None	WT	WT	None	None	113
L023	SCC	WT	G12S	None	AMP	WT	G12S	None	AMP	0
L030	SCC	WT	Q61H	None	None	WT	Q61H	None	None	25
L104	SCC	WT	WT	None	None	WT	WT	None	None	46
L110	SCC	WT	WT	None	None	WT	WT	None	None	78
L115	SCC	Exon19Del	WT	None	None	Exon19Del	WT	None	None	199
L121	SCC	WT	WT	AMP	None	WT	WT	AMP	None	23
L123	SCC	WT	WT	N/A	None	WT	WT	AMP	None	47
L133	SCC	WT	WT	AMP	None	WT	WT	AMP	None	N/A
L140	SCC	WT	WT	None	None	WT	WT	None	None	N/A

ISSN: 1479-5876