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Table 2 Relationship of model establishment rate and patients’ clinical information

From: Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies

Patient information Patient # Derived model # Established rate (%) P value (univariate) P value (multivariate)
Sex     0.0115 0.1896
Male 24 10 42   
Female 7 0 0   
Histologic type     0.0015 0.0218
SCC 15 9 60   
AC 16 1 6   
Pathologic stage     0.5017 n/a
Stage I 12 2 17   
Stage II 7 3 43   
Stage III/IV 11 4 36   
Smoke status     0.0228 0.4631
Smoker 14 7 50   
Non-smoker 16 2 12.5   
Mutation     0.1031 n/a
EGFR 7 1 14   
KRAS 3 2 67