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Figure 2 | Journal of Translational Medicine

Figure 2

From: Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC

Figure 2

Gene expression in LLABCs and HFDs, (A) FOXP3, (B) CTLA-4: Mean FOXP3 and CTLA-4 gene expression over β actin in the circulation in women with LLABCs (n = 16); baseline (T1), following eight cycles of NAC (T6) and post-surgery (T7). Patients allocated into groups according to histological responses elicited in the breast cancers after NAC: Group I-cPR; Group II-VGR; Group III-partial response; IV-poor or no response. Statistical analysis: (A) FOXP3 (Group I & II): T1 v HFD (p = 0.006); T1 v T6 (NS); T1 v T7 (NS); T6 v HFD (NS); T7 v HFD (p = 0.002). (A) FOXP3 (Group III & V): T1 v HFD (p = 0.050); T1 v T6 (NS); T1 v T7 (NS); T6 v HFD (NS); T7 v HFD (p = 0.001). (B) CTLA-4 (Group I & II): T1 v HFD (p = 0.011); T1vT6 (NS); T1vT7 (NS); T6 v HFD (NS); T7 v HFD (p = 0.002). (B) CTLA-4 (Group III & IV): T1 v HFD (p = 0.038); T1 v T6 (NS); T1 v T7 (NS); T6 v HFD (NS); T7 v HFD (p = 0.041). Group I & II (T1) v III & IV (T1) (NS). Clear columns are good pathological responders whilst shaded columns are poor pathological responders to NAC.

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Journal of Translational Medicine

ISSN: 1479-5876

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