Skip to main content

Advertisement

Table 1 Clinical characteristics of HNF1A- and HNF4A-MODY subjects

From: Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young

  HNF1A-MODY median (IQR) HNF4A-MODY median (IQR) P value
n (male/female) 33 (14/19) 9 (4/5) 0.91 NS
Age (years) 38 (21–51) 32 (23–46) 0.57 NS
Duration of diabetes (years) 6 (3–18) 7 (0–16) 0.42 NS
Body mass index (kg/m 2 ) 24.4 (22.0–26.2) 23.9 (21.8–25.0) 0.55 NS
Systolic blood pressure (mmHg) 122 (116–131) 115 (109–129) 0.27 NS
Diastolic blood pressure (mmHg) 71 (67–80) 73 (67–79) 0.83 NS
Total cholesterol (mmol/L) 4.3 (3.6–4.9) 3.7 (3.4–4.3) 0.12 NS
LDL cholesterol (mmol/L) 2.5 (2.1–3.0) 2.2 (1.8–2.7) 0.14 NS
HDL cholesterol (mmol/L) 1.3 (1.1–1.7) 1.2 (0.8–1.6) 0.28 NS
TG (mmol/L) 0.71 (0.55–0.92) 0.62 (0.52–0.79) 0.23 NS
HbA 1c (%) 7.1 (6.3–8.0) 5.7 (5.3–7.1) 0.045 *
Fasting plasma glucose (mmol/L) 6.8 (5.3–8.6) 5.0 (3.8–7.2) 0.09 NS
WCC (x10 9 /L) 6.76 (5.62–8.52) 6.66 (5.94–7.89) 0.71 NS
Neutrophil count (x10 9 /L) 4.06 (3.30–5.73) 3.70 (3.07–4.47) 0.21 NS
Patients treated with aspirin (n) 10 2 0.63 NS
Patients treated with statin (n) 8 1 0.40 NS
  1. Results are expressed in median and interquartile range (IQR). *: significant; NS: not significant; LDL/HDL: low-density/high-density lipoprotein; TG: triglycerides; WCC: white cell count; Mann–Whitney U test for HNF1A-MODY vs. HNF4A-MODY revealed no statistically significant differences but for HbA1c. Male/female ratio and treatment with aspirin or statins were tested for statistical difference using the χ2 test.