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Table 1 Clinical characteristics of HNF1A- and HNF4A-MODY subjects

From: Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young

 

HNF1A-MODY median (IQR)

HNF4A-MODY median (IQR)

P value

n (male/female)

33 (14/19)

9 (4/5)

0.91 NS

Age (years)

38 (21–51)

32 (23–46)

0.57 NS

Duration of diabetes (years)

6 (3–18)

7 (0–16)

0.42 NS

Body mass index (kg/m 2 )

24.4 (22.0–26.2)

23.9 (21.8–25.0)

0.55 NS

Systolic blood pressure (mmHg)

122 (116–131)

115 (109–129)

0.27 NS

Diastolic blood pressure (mmHg)

71 (67–80)

73 (67–79)

0.83 NS

Total cholesterol (mmol/L)

4.3 (3.6–4.9)

3.7 (3.4–4.3)

0.12 NS

LDL cholesterol (mmol/L)

2.5 (2.1–3.0)

2.2 (1.8–2.7)

0.14 NS

HDL cholesterol (mmol/L)

1.3 (1.1–1.7)

1.2 (0.8–1.6)

0.28 NS

TG (mmol/L)

0.71 (0.55–0.92)

0.62 (0.52–0.79)

0.23 NS

HbA 1c (%)

7.1 (6.3–8.0)

5.7 (5.3–7.1)

0.045 *

Fasting plasma glucose (mmol/L)

6.8 (5.3–8.6)

5.0 (3.8–7.2)

0.09 NS

WCC (x10 9 /L)

6.76 (5.62–8.52)

6.66 (5.94–7.89)

0.71 NS

Neutrophil count (x10 9 /L)

4.06 (3.30–5.73)

3.70 (3.07–4.47)

0.21 NS

Patients treated with aspirin (n)

10

2

0.63 NS

Patients treated with statin (n)

8

1

0.40 NS

  1. Results are expressed in median and interquartile range (IQR). *: significant; NS: not significant; LDL/HDL: low-density/high-density lipoprotein; TG: triglycerides; WCC: white cell count; Mann–Whitney U test for HNF1A-MODY vs. HNF4A-MODY revealed no statistically significant differences but for HbA1c. Male/female ratio and treatment with aspirin or statins were tested for statistical difference using the χ2 test.