From: Cellular immunotherapy for refractory hematological malignancies
Donor eligibility criteria | Â |
---|---|
Inclusion criteria | Biological family members |
 | 3/6 HLA match (using loci A, B, DR) |
 | 18 years of age |
 | No malignancy in the past 5 years except for non-melanoma skin cancers |
 | Normal CBC |
 | β-HCG urine or serum negative if donor is of childbearing age |
 | Adequate venous access so leukapheresis can be performed via standard peripheral IV |
Exclusion criteria | HIV-1 or 2, syphilis, hepatitis B or C, HTLV 1 or 2, CMV, Chagas, and West Nile Virus positive |
 | Symptomatic congestive heart failure (CHF) |
 | Oxygen dependant chronic obstructive lung disease (COPD) |
 | Cirrhosis or active liver disease |
 | History of any lymphoid, myeloid or other non-solid malignancy |
 | History of transplantation |