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Table 1 Clinical arguments for the immunoediting hypothesis in epithelial ovarian carcinoma

From: Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer

Authors Year Findings
Spontaneous anti-tumor response
Zhang L et al. [21] 2003 Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival
Raspollini NR et al. [22] 2005 Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival (plus chemotherapeutic response)
Sato E et al. [23] 2005 Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival
Hamanishi J et al. [24] 2007 Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival
Clarke B et al. [25] 2008 Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival (only for high grade serous EOC, but not for endometrioïd or mucinous EOC)
Shah CA et al. [26] 2008 Association between intraepithelial T-cell infiltration (TIL CD8+) and optimal debulking surgery
Tomsova M et al. [27] 2008 Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival
Callahan MJ et al. [38] 2008 Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival
Han LY et al. [28] 2008 Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival
Stumpf M et al. [29] 2009 Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival
Leffers N et al. [30, 39] 2009 Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival
Milne K et al. [31] 2009 Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival
Adams SF et al. [32] 2009 Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival
Kryczek I et al. [35] 2009 Association between intraepithelial T-cell infiltration (TIL CD4+ with IL-17 secretion) and patient survival
Tumor immune evasion
Curiel TJ et al. [36] 2004 Inverse association between survival and intratumoral regulatory T cells (CD4+CD25+FoxP3+)
Wolf D et al. [40] 2005 Inverse association between survival and intratumoral regulatory T cells (FoxP3+)
Dong HP et al. [41] 2006 Inverse association between survival and intratumoral NK (CD3- CD16+) or B cells (CD19+)
Kryczek I et al. [42] 2007 Inverse association between survival and intratumoral B7-H4+ macrophage or regulatory T cells (FoxP3+)
Hamanishi J et al. [24] 2007 PD-L1 expression by tumor predicts low T-cell infiltration
Buckanovitch RJ et al. [43] 2008 Endothelin B receptor (ETBR) expression restricts T-cell infiltration and predicts poor survival
Labidi-Galy SI [44, 45] 2011 Inverse association between survival and intratumoral pDC (CD4+, CD123+, BDCA2+)
  1. PD-1: programmed cell death 1; PD-L1: PD-1 ligand 1; ETBR: endothelin B receptor; pDC: plasmacytoïd dendritic cells.