Table 1 Clinical arguments for the immunoediting hypothesis in epithelial ovarian carcinoma
From: Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer
Authors | Year | Findings |
|---|---|---|
Spontaneous anti-tumor response | ||
Zhang L et al. [21] | 2003 | Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival |
Raspollini NR et al. [22] | 2005 | Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival (plus chemotherapeutic response) |
Sato E et al. [23] | 2005 | Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival |
Hamanishi J et al. [24] | 2007 | Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival |
Clarke B et al. [25] | 2008 | Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival (only for high grade serous EOC, but not for endometrioïd or mucinous EOC) |
Shah CA et al. [26] | 2008 | Association between intraepithelial T-cell infiltration (TIL CD8+) and optimal debulking surgery |
Tomsova M et al. [27] | 2008 | Association between intraepithelial T-cell infiltration (TIL CD3+) and patient survival |
Callahan MJ et al. [38] | 2008 | Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival |
Han LY et al. [28] | 2008 | Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival |
Stumpf M et al. [29] | 2009 | Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival |
2009 | Association between intraepithelial T-cell infiltration (TIL CD8+) and patient survival | |
Milne K et al. [31] | 2009 | Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival |
Adams SF et al. [32] | 2009 | Association between intraepithelial T-cell infiltration (TIL CD3+ and CD8+) and patient survival |
Kryczek I et al. [35] | 2009 | Association between intraepithelial T-cell infiltration (TIL CD4+ with IL-17 secretion) and patient survival |
Tumor immune evasion | ||
Curiel TJ et al. [36] | 2004 | Inverse association between survival and intratumoral regulatory T cells (CD4+CD25+FoxP3+) |
Wolf D et al. [40] | 2005 | Inverse association between survival and intratumoral regulatory T cells (FoxP3+) |
Dong HP et al. [41] | 2006 | Inverse association between survival and intratumoral NK (CD3- CD16+) or B cells (CD19+) |
Kryczek I et al. [42] | 2007 | Inverse association between survival and intratumoral B7-H4+ macrophage or regulatory T cells (FoxP3+) |
Hamanishi J et al. [24] | 2007 | PD-L1 expression by tumor predicts low T-cell infiltration |
Buckanovitch RJ et al. [43] | 2008 | Endothelin B receptor (ETBR) expression restricts T-cell infiltration and predicts poor survival |
2011 | Inverse association between survival and intratumoral pDC (CD4+, CD123+, BDCA2+) | |