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Table 2 IVS5-13insC genotype frequencies and associations with diabetes overall and by race/ethnicity

From: Lack of association of the HMGA1 IVS5-13insC variant with type 2 diabetes in an ethnically diverse hypertensive case control cohort

    

Unadjusted

 

Adjusted

 

Race/ethnic group

MAF (cases)

MAF (controls)

HWE p value*

Odds ratio (95%CI)

p value

Odds ratio (95%CI)†

p value†

Overall

0.053

0.052

-

1.00 (0.79-1.26)

0.98

0.98 (0.76-1.26)

0.88

(n=3070)

       

Caucasian

0.028

0.036

0.40

0.75 (0.46-1.22)

0.25

0.95 (0.44-2.06)

0.90

(n=1101)

       

Hispanic

0.074

0.070

0.20

1.09 (0.82-1.45)

0.57

0.79 (0.49-1.25)

0.31

(n=1579)

       

African American (n=369)

0.030

0.039

0.10

0.83 (0.36-1.90)

0.65

1.51 (0.48-4.74)

0.48

  1. 95%CI indicates 95% confidence interval; MAF, minor allele frequency, HWE, Hardy Weinberg Equilibrium.
  2. *Hardy Weinberg Equilibrium p value calculated using a chi square test by race/ethnicity in non-diabetic patients. †Generated using logistic regression in a dominant model adjusted for age, gender, body mass index, and Caucasian, African, and Native American ancestry as estimated by ancestry informative markers.
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Journal of Translational Medicine

ISSN: 1479-5876

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