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Table 2 IVS5-13insC genotype frequencies and associations with diabetes overall and by race/ethnicity

From: Lack of association of the HMGA1 IVS5-13insC variant with type 2 diabetes in an ethnically diverse hypertensive case control cohort

     Unadjusted   Adjusted  
Race/ethnic group MAF (cases) MAF (controls) HWE p value* Odds ratio (95%CI) p value Odds ratio (95%CI) p value
Overall 0.053 0.052 - 1.00 (0.79-1.26) 0.98 0.98 (0.76-1.26) 0.88
(n=3070)        
Caucasian 0.028 0.036 0.40 0.75 (0.46-1.22) 0.25 0.95 (0.44-2.06) 0.90
(n=1101)        
Hispanic 0.074 0.070 0.20 1.09 (0.82-1.45) 0.57 0.79 (0.49-1.25) 0.31
(n=1579)        
African American (n=369) 0.030 0.039 0.10 0.83 (0.36-1.90) 0.65 1.51 (0.48-4.74) 0.48
  1. 95%CI indicates 95% confidence interval; MAF, minor allele frequency, HWE, Hardy Weinberg Equilibrium.
  2. *Hardy Weinberg Equilibrium p value calculated using a chi square test by race/ethnicity in non-diabetic patients. †Generated using logistic regression in a dominant model adjusted for age, gender, body mass index, and Caucasian, African, and Native American ancestry as estimated by ancestry informative markers.