Skip to main content

Protective effects of berberine on doxorubicin-induced nephrotoxicity in mice

Background and purpose

Doxorubicin, a very potent and often used anti-cancer drug, is largely limited due to the dose-related toxic effects. The present study investigated whether berberine, a natural product alkaloid, can reduce the renal injury induced by doxorubicin.

Experimental approach

Mice of either gender were randomly divided into four groups: the control group, doxorubicin group, berberine group, and berberine+doxorubicin group. In the tests, body weight, general condition and mortality of the mice were observed, and serum blood urea nitrogen (BUN) and serum albumin (Alb) levels were determined to evaluate renal function. Furthermore, the renal was excised for determination of the weight changes, as well as histopathological analysis in the tissues.

Key results

Mortality rate and significant decline in body weight, and increased blood urea nitrogen (BUN) and serum albumin (Alb) levels were observed in doxorubicin-treated mice. These changes were significantly prevented by pretreatment with berberine. Histopathological studies showed that doxorubicin caused structural injuries, such as glomerular, tubular epithelial alterations and interstitial edema in the renal. These histopathological changes were largely attenuated by berberine pretreatment.

Conclusions

These findings indicate that berberine could play an important role in ameliorating the doxorubicin-induced toxicity.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Xiaoyan Zhao.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Zhao, X., Tong, N. Protective effects of berberine on doxorubicin-induced nephrotoxicity in mice. J Transl Med 10, A66 (2012). https://doi.org/10.1186/1479-5876-10-S2-A66

Download citation

Keywords

  • Doxorubicin
  • Alkaloid
  • Weight Change
  • Serum Blood
  • Blood Urea Nitrogen