Figure 2

Immunohistochemical staining for FLJ10540 and osteopontin and overall survival in patients with NPC. (A) The FLJ10540 and osteopontin intensities in various tissues were evaluated by immunohistochemical staining. FLJ10540 and osteopontin immunohistochemical staining intensities are shown in tumor and normal tissues. Normal tissues displayed very weak FLJ10540 and osteopontin staining in the cytoplasm (a, and f). The stainings for FLJ10540 and osteopontin were higher in tumor tissues (b-e and g-j). Significant cytoplasm expressions of FLJ10540 and osteopontin were observed in early (b, and g) and late (c, and h) stage tumors. Original magnification ×100. (B) The survival period of those patients (n=63) with strong expressions of FLJ10540 and osteopontin (dashed lines) were significantly shorter than for those with lower expressions of FLJ10540 and osteopontin (solid line). The difference in survival was statistically significant (p<0.001) according to the log-rank test.