Figure 4

Effects of trehalose on cerebral vasospasm in experimental SAH (post-administration model). Saline, 30% trehalose, or 30% maltose was injected into the cisterna magna at 3 h after the experimental SAH induction. (A) Representative angiograms of the basilar arteries prior to (Pre) and 48 h after (Post) the induction of experimental SAH in rabbits. (B) The graph shows the diameter ratios of the basilar arteries after the induction of experimental SAH to the basilar arteries prior to the induction. *P < 0.05 (Kruskal-Wallis test). n = 6 in each group. (C) Upper panels, representative H&E-stained paraffin sections (3 μm thick) of basilar arteries. Scale bars, 1000 μm. Lower panels, higher magnifications of the squares in the upper panels. Scale bars, 100 μm. (D) The graph shows the cross-section of basilar artery in each group. *P < 0.05 (Kruskal-Wallis test). n = 6 in each group. All experiments were repeated more than three times. The boxes in graphs indicate the 25th and 75th quartiles and the central line is the median. The whiskers extend from the lowest to the highest value. Values outside the range of the whiskers are extreme values.