Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

Table 5 Percentage change of pharmacodynamic parameters according to SLCO1B1 c.388A > G, SLCO1B1 c.521T > C and SLCO1B3 int7A > G genotypes and SLCO1B1 haplotypes after 12 months of raloxifene treatment in 53 postmenopausal women

Pharmacodynamic parameter	Δ FN BMD (%)		Δ QUI (%)		Δ OC (%)
genotype	SLCO1B1 c.388A > G		SLCO1B1 c.521T > C		SLCO1B3 int7C > G
	AA	−1.1 (1.5)	TT	2.5 (1.1)	CC	−21.0 (3.5)
	AG	3.4 (0.6)	TC	−1.6 (1.4)	non CC	−33.5 (3.5)
	GG	−0.6 (1.1)
test/p-value	ANOVA	0.001 ^a	t-test	0.033	t-test	0.015
Pharmacodynamic parameter	Δ FN BMD (%)		Δ CTX (%)		Δ SOS (%)		Δ QUI(%)
haplotype	*1a		*1b		*15		*15
	0 copies	−0.65 (1.1)	0 copies	−20.7 (6.7)	0 copies	0.2 (0.1)	0 copies	2.4 (1.1)
	1 copy	3.5 (0.6)	1 copy	−24.7 (5.1)	1 copy	−0.3 (0.2)	1 copy	−1.9 (1.6)
	2 copies	−2.0 (1.6)	2 copies	−56.9 (10.4)
test/p-value test/p-value	ANOVA	0.0002 ^b	ANOVA	0.039 ^c	t-test	0.031	t-test	0.03

The values are presented as means (standard errors).
^aBonferoni test (ANOVA), p = 0.004 for AA vs. AG, =0.021 for AG vs. GG.
^bBonferoni test (ANOVA), p = 0.013 for 0 vs. 1, p = 0.0004 for 1 vs. 2 copies of haplotype*1a.
^cBonferoni test (ANOVA), p = 0.035 for 0 vs. 2 copies of haplotype*1b.
Δ FN BMD (%), percentage change of femoral neck bone mineral density; Δ QUI (%), percentage change of quantitative ultrasound index; Δ OC (%), percentage change of osteocalcin; Δ CTX (%), percentage change of serum C-terminal telopeptide fragments of type I collagen; Δ SOS (%), percentage change of heel speed of sound.

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