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Table 4 Summary of concentrations of raloxifene species by haplotype

From: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

  SLCO1B1 haplotype
  *1b *15 *1a
No. of haplotype copies 0 1 2 p value (ANOVA) 0 1 p value (t-test) 0 1 2 p value (ANOVA)
M1 (nmol/l) 61.8 (12.0) 72.9 (15.0) 92.6 (17.3) 0.437 66.0 (11.0) 78.4 (16.0) 0.497 99.4 (19.0) 64.3 (11.5) 55.9 (20.5) 0.125
M2 (nmol/l) 334.1 (72.0) 281.3 (57.1) 412.3 (122.9) 0.625 264.2 (42.5) 422.1 (90.8) 0.138 439.2 (101.7) 298.7 (52.3) 231.7 (93.0) 0.18
M3 (nmol/l) 305.8 (60.2) 482.7 (87.1) 1,572.3 (616.9) 0.0004 a 533.1 (125.9) 462.3 (81.8) 0.954 1,072.7 (305.2) 388.1 (70.2) 273.3 (99.0) 0.001 d
RAL
(nmol/l)
2.7 (0.5) 3.7 (0.5) 7.2 (1.8) 0.016b 3.5
(0.5)
3.8 (0.5) 0.343 5.6 (0.9) 3.5 (0.5) 1.7 (0.6) 0.002e
TR (nmol/I) 704.4 (137.6) 840.6 (154.0) 2,084.4 (751.6) 0.02c 866.8 (168.1) 966.9 (380.7) 0.549 1,616.9 (380.7) 754.6 (124.6) 592.6 (202.9) 0.007f
  1. The values of concentrations are presented as means (standard errors).
  2. aBonferoni test (ANOVA), p = 0.004 for 1 vs. 2 copies, p =0.0003 for 0 vs. 2 copies.
  3. b Bonferoni test (ANOVA), p = 0.014 for 0 vs. 2 copies.
  4. cBonferoni test (ANOVA), p = 0.017 for 0 vs 2 copies.
  5. dBonferoni test (ANOVA), p = 0.004 for 0 vs. 1 copies, p =0.008 for 0 vs. 2 copies.
  6. eBonferoni test (ANOVA), p = 0.003 for 0 vs. 2 copies.
  7. fBonferoni test (ANOVA), p = 0.016 for 0 vs. 1 copies, p =0.019 for 0 vs. 2 copies.
  8. M1, raloxifene-6-β-glucuronide; M2, raloxifene-4'- β –glucuronide; M3, raloxifene-6,4'- di –glucuronide; RAL, raloxifene; TR, total raloxifene.