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Table 4 Summary of concentrations of raloxifene species by haplotype

From: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

 

SLCO1B1 haplotype

 

*1b

*15

*1a

No. of haplotype copies

0

1

2

p value (ANOVA)

0

1

p value (t-test)

0

1

2

p value (ANOVA)

M1 (nmol/l)

61.8 (12.0)

72.9 (15.0)

92.6 (17.3)

0.437

66.0 (11.0)

78.4 (16.0)

0.497

99.4 (19.0)

64.3 (11.5)

55.9 (20.5)

0.125

M2 (nmol/l)

334.1 (72.0)

281.3 (57.1)

412.3 (122.9)

0.625

264.2 (42.5)

422.1 (90.8)

0.138

439.2 (101.7)

298.7 (52.3)

231.7 (93.0)

0.18

M3 (nmol/l)

305.8 (60.2)

482.7 (87.1)

1,572.3 (616.9)

0.0004 a

533.1 (125.9)

462.3 (81.8)

0.954

1,072.7 (305.2)

388.1 (70.2)

273.3 (99.0)

0.001 d

RAL

(nmol/l)

2.7 (0.5)

3.7 (0.5)

7.2 (1.8)

0.016b

3.5

(0.5)

3.8 (0.5)

0.343

5.6 (0.9)

3.5 (0.5)

1.7 (0.6)

0.002e

TR (nmol/I)

704.4 (137.6)

840.6 (154.0)

2,084.4 (751.6)

0.02c

866.8 (168.1)

966.9 (380.7)

0.549

1,616.9 (380.7)

754.6 (124.6)

592.6 (202.9)

0.007f

  1. The values of concentrations are presented as means (standard errors).
  2. aBonferoni test (ANOVA), p = 0.004 for 1 vs. 2 copies, p =0.0003 for 0 vs. 2 copies.
  3. b Bonferoni test (ANOVA), p = 0.014 for 0 vs. 2 copies.
  4. cBonferoni test (ANOVA), p = 0.017 for 0 vs 2 copies.
  5. dBonferoni test (ANOVA), p = 0.004 for 0 vs. 1 copies, p =0.008 for 0 vs. 2 copies.
  6. eBonferoni test (ANOVA), p = 0.003 for 0 vs. 2 copies.
  7. fBonferoni test (ANOVA), p = 0.016 for 0 vs. 1 copies, p =0.019 for 0 vs. 2 copies.
  8. M1, raloxifene-6-β-glucuronide; M2, raloxifene-4'- β –glucuronide; M3, raloxifene-6,4'- di –glucuronide; RAL, raloxifene; TR, total raloxifene.
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Journal of Translational Medicine

ISSN: 1479-5876

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