Table 2 Genotype and haplotype frequencies of SLCO polymorphisms in 53 postmenopausal patients with osteoporosis
SLCO variant | genotype | number of patients | frequency (%) |
|---|---|---|---|
SLCO1B1 c.388A > G | AA | 14 | 26.4 |
AG | 28 | 52.8 | |
GG | 11 | 20.8 | |
SLCO1B1 c.521T > C | TT | 35 | 66.0 |
TC | 18 | 34.0 | |
CC | 0 | 0 | |
SLCO1B3 int7C > G | CC | 36 | 67.9 |
CG | 16 | 30.2 | |
GG | 1 | 1.9 | |
SLCO1B1 haplotype | number haplotype copies | ||
*1a (reference haplotype) | 0 | 11 | 20.8 |
1 | 30 | 56.6 | |
2 | 12 | 22.6 | |
*1b (c.388A > G) | 0 | 24 | 45.3 |
1 | 24 | 45.3 | |
2 | 5 | 9.4 | |
*5 (c.521T > C) | 0 | 51 | 96.2 |
1 | 2 | 3.8 | |
2 | 0 | 0 | |
*15 (c.388A > G and c.521T > C) | 0 | 37 | 69.8 |
1 | 16 | 30.2 | |
2 | 0 | 0 |