Figure 1

Gene expression profiling after dose standardization of SNP. A) Serum Nitrite concentration (μM). Values are mean ± SEM; n = 6. ^*P < 0.05 for SNP 100 mM vs. control; ^#P < 0.05 for SNP 100 mM vs. SNP 50 mM. B) mRNA expression after 4 weeks of treatment showed significantly reduced expression of α-SMA, collagen1α1, TIMP1 and NF-кB compared to CCl₄ group. On the other hand, Albumin mRNA expression showed significant improvement after SNP-MSCs treatment. P-value < 0.05 was considered significant n = 3.^*P < 0.05 for SNP-MSCs vs. CCl₄; ^#P < 0.05 for SNP-MSCs vs. MSCs; ^φP < 0.05 for SNP-MSCs vs. SNP. C) Expression (%) of SMA+/TUNEL + cells in all groups indicating HSC apoptosis after SNP administration. ^***P < 0.001 for SNP vs. CCl₄; ^###P < 0.001 for SNP-MSCs vs. CCl₄.