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Table 1 A table of IFN-γ secretion in response to HLA matched and mismatched cell lines and to T2 cell pulsed with peptide recognized by the transduced TCR

From: Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor

  Melanoma Cell Lines T2 cells pulsed with peptide (μM/ml)
    938 624 Irrelevant Peptide Specific Peptide
  TCR Bioreactor A2- A2+ 1.0 1.0 0.1 0.01 0.001 0.0001
NY-ESO Patient 1 Static Bags 40 19300 44 > 126650 45600 5095 1080 136
   Wave 68 46950 128 > 182100 83200 23350 2770 646
  Patient 2 Static Bags 345 39700 694 > 241000 52250 4195 985 339
   Wave 410 40700 1876 > 219650 58400 8650 2374 1302
  Patient 3 Static Bags 79 > 31250 84 > 84800 23850 2425 242 40
   Wave 78 > 30150 120 > 83000 31500 4830 534 139
  Patient 4 Static Bags 16 4725 27 11045 1075 166 45 29
   Wave 18 5770 43 12445 1610 236 54 33
  Patient 5 Static Bags 7 11780 855 > 113300 25555 2635 1346 14
   Wave 1201 16140 147 > 125300 63400 8230 469 177
  Patient 6 Static Bags 129 3505 105 9535 1080 147 40 12
   Wave 36 4000 99 26950 2560 315 118 80
  Patient 7 Static Bags 23 6565 40 24750 3445 818 393 159
   Wave 78 3550 290 > 45100 6240 911 441 204
MART-1 Patient 8 Static Bags 98 > 77225 160 > 58200 11480 1375 544 NA
   Wave 148 91625 547 62200 20875 3630 1510 NA
  Patient 9 Static Bags 12 66500 30 > 180600 93700 370 490 NA
   Wave 65 > 162700 197 > 260700 > 154600 3000 2897 NA
gp154 Patient 10 Static Bags 18 32950 22 NA 4360 2600 739 479
   Wave 18 42650 55 NA 8075 5290 1785 684