Table 2 The relationship of clinicopathological variables and immunohistochemical features with overall survival (OS) in laryngeal squamous cell carcinoma patients
Feature | No. of patients | Overall survival (%) | χ 2 | P a | ||
|---|---|---|---|---|---|---|
| Â | Â | 3 y | 5 y | 10 y | Â | Â |
Gender | Â | Â | Â | 1.539 | 0.215 | |
Female | 3(2.0%) | 100 | 100 | 100 | Â | Â |
Male | 145(98.0%) | 77.2 | 71.0 | 55.6 | Â | Â |
Age (years)b | Â | Â | Â | 0.019 | 0.889 | |
< 60 | 72(48.6%) | 80.6 | 72.2 | 54.9 | Â | Â |
≥60 | 76(51.4%) | 75 | 71.1 | 57.6 |  |  |
Histological grade | Â | Â | Â | 2.976 | 0.226 | |
Well | 70(47.3%) | 85.7 | 81.4 | 60.8 | Â | Â |
Moderately | 58(39.2%) | 69.0 | 62.1 | 51.2 | Â | Â |
Poorly | 20(13.5%) | 75.0 | 65.0 | 55.0 | Â | Â |
Smoking indexc | Â | Â | Â | 3.745 | 0.053 | |
< 600 | 67(45.3%) | 83.6 | 77.6 | 66.2 | Â | Â |
≥600 | 81(54.7%) | 72.8 | 66.7 | 48.4 |  |  |
Alcohol consumption | Â | Â | Â | 0.033 | 0.856 | |
No | 88(59.5%) | 79.5 | 71.6 | 56.8 | Â | Â |
Yes | 60(40.5%) | 75.0 | 71.7 | 55.6 | Â | Â |
Primary Site | Â | Â | Â | 8.974 | 0.011* | |
Glottic | 104(70.3%) | 82.7 | 77.9 | 63.1 | Â | Â |
Supraglottic | 39(26.3%) | 64.1 | 53.8 | 39.0 | Â | Â |
Subglottic | 5(3.4%) | 80.0 | 80.0 | 40.0 | Â | Â |
T Stage | Â | Â | Â | 6.201 | 0.013* | |
1-2 | 101(68.2%) | 81.2 | 78.2 | 62.6 | Â | Â |
3-4 | 47(31.8%) | 70.2 | 57.4 | 43.5 | Â | Â |
Cervical lymph node metastasis | Â | Â | Â | 21.263 | < 0.001** | |
Negative | 129(87.2%) | 82.9 | 77.5 | 61.7 | Â | Â |
Positive | 19(12.8%) | 42.1 | 31.6 | 21.1 | Â | Â |
TNM Stage | Â | Â | Â | 7.736 | 0.005** | |
I-II | 96(64.9%) | 82.3 | 79.6 | 63.8 | Â | Â |
III-IV | 52(35.1%) | 69.2 | 57.7 | 43.3 | Â | Â |
Total radiation dose | Â | Â | Â | 1.671 | 0.196 | |
< 60 Gy | 61(41.2%) | 78.7 | 75.4 | 62.9 | Â | Â |
≥60 Gy | 87(58.8%) | 77.0 | 69.0 | 51.7 |  |  |
Margin | Â | Â | Â | 0.395 | 0.530 | |
Negative | 68(45.9%) | 82.4 | 76.5 | 57.9 | Â | Â |
Positive | 80(54.1%) | 73.8 | 67.5 | 55.0 | Â | Â |
TGM2 | Â | Â | Â | 6.308 | 0.012* | |
High | 70(47.3%) | 72.9 | 64.3 | 45.5 | Â | Â |
Low | 78(52.7%) | 82.1 | 78.2 | 65.7 | Â | Â |
BNIP3 | Â | Â | Â | 8.586 | 0.003** | |
High | 106(71.6%) | 79.2 | 75.5 | 64.4 | Â | Â |
Low | 42(28.4%) | 71.4 | 61.9 | 35.7 | Â | Â |
TGM2 & BNIP3 | Â | Â | Â | 19.021 | < 0.001** | |
TGM2 (-) & BNIP3 (+) | 49(33.1%) | 87.8 | 85.7 | 76.9 | Â | Â |
TGM2 (+) & BNIP3 (-) | 13(8.8%) | 69.2 | 53.8 | 15.4 | Â | Â |
TGM2 (+) & BNIP3 (+) | 57(38.5%) | 73.7 | 66.7 | 53.8 | Â | Â |
TGM2 (-) & BNIP3 (-) | 29(19.6%) | 72.4 | 65.5 | 46.3 | Â | Â |