|
Feature
|
No. of patients
|
Overall survival (%)
|
χ
2
|
P
a
|
|---|
| | |
3 y
|
5 y
|
10 y
| | |
|---|
|
Gender
| | | |
1.539
|
0.215
|
|
Female
|
3(2.0%)
|
100
|
100
|
100
| | |
|
Male
|
145(98.0%)
|
77.2
|
71.0
|
55.6
| | |
|
Age (years)b
| | | |
0.019
|
0.889
|
|
< 60
|
72(48.6%)
|
80.6
|
72.2
|
54.9
| | |
|
≥60
|
76(51.4%)
|
75
|
71.1
|
57.6
| | |
|
Histological grade
| | | |
2.976
|
0.226
|
|
Well
|
70(47.3%)
|
85.7
|
81.4
|
60.8
| | |
|
Moderately
|
58(39.2%)
|
69.0
|
62.1
|
51.2
| | |
|
Poorly
|
20(13.5%)
|
75.0
|
65.0
|
55.0
| | |
|
Smoking indexc
| | | |
3.745
|
0.053
|
|
< 600
|
67(45.3%)
|
83.6
|
77.6
|
66.2
| | |
|
≥600
|
81(54.7%)
|
72.8
|
66.7
|
48.4
| | |
|
Alcohol consumption
| | | |
0.033
|
0.856
|
|
No
|
88(59.5%)
|
79.5
|
71.6
|
56.8
| | |
|
Yes
|
60(40.5%)
|
75.0
|
71.7
|
55.6
| | |
|
Primary Site
| | | |
8.974
|
0.011*
|
|
Glottic
|
104(70.3%)
|
82.7
|
77.9
|
63.1
| | |
|
Supraglottic
|
39(26.3%)
|
64.1
|
53.8
|
39.0
| | |
|
Subglottic
|
5(3.4%)
|
80.0
|
80.0
|
40.0
| | |
|
T Stage
| | | |
6.201
|
0.013*
|
|
1-2
|
101(68.2%)
|
81.2
|
78.2
|
62.6
| | |
|
3-4
|
47(31.8%)
|
70.2
|
57.4
|
43.5
| | |
|
Cervical lymph node metastasis
| | | |
21.263
|
< 0.001**
|
|
Negative
|
129(87.2%)
|
82.9
|
77.5
|
61.7
| | |
|
Positive
|
19(12.8%)
|
42.1
|
31.6
|
21.1
| | |
|
TNM Stage
| | | |
7.736
|
0.005**
|
|
I-II
|
96(64.9%)
|
82.3
|
79.6
|
63.8
| | |
|
III-IV
|
52(35.1%)
|
69.2
|
57.7
|
43.3
| | |
|
Total radiation dose
| | | |
1.671
|
0.196
|
|
< 60 Gy
|
61(41.2%)
|
78.7
|
75.4
|
62.9
| | |
|
≥60 Gy
|
87(58.8%)
|
77.0
|
69.0
|
51.7
| | |
|
Margin
| | | |
0.395
|
0.530
|
|
Negative
|
68(45.9%)
|
82.4
|
76.5
|
57.9
| | |
|
Positive
|
80(54.1%)
|
73.8
|
67.5
|
55.0
| | |
|
TGM2
| | | |
6.308
|
0.012*
|
|
High
|
70(47.3%)
|
72.9
|
64.3
|
45.5
| | |
|
Low
|
78(52.7%)
|
82.1
|
78.2
|
65.7
| | |
|
BNIP3
| | | |
8.586
|
0.003**
|
|
High
|
106(71.6%)
|
79.2
|
75.5
|
64.4
| | |
|
Low
|
42(28.4%)
|
71.4
|
61.9
|
35.7
| | |
|
TGM2 & BNIP3
| | | |
19.021
|
< 0.001**
|
|
TGM2 (-) & BNIP3 (+)
|
49(33.1%)
|
87.8
|
85.7
|
76.9
| | |
|
TGM2 (+) & BNIP3 (-)
|
13(8.8%)
|
69.2
|
53.8
|
15.4
| | |
|
TGM2 (+) & BNIP3 (+)
|
57(38.5%)
|
73.7
|
66.7
|
53.8
| | |
|
TGM2 (-) & BNIP3 (-)
|
29(19.6%)
|
72.4
|
65.5
|
46.3
| | |
- a Log-rank test. b Patients were divided into two groups according to the median age. c Smoking index is defined as the number of cigarettes used per day × the total smoking time (years). *P < 0.05, **P < 0.01
