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Table 2 The relationship of clinicopathological variables and immunohistochemical features with overall survival (OS) in laryngeal squamous cell carcinoma patients

From: Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Feature No. of patients Overall survival (%) χ 2 P a
   3 y 5 y 10 y   
Gender     1.539 0.215
Female 3(2.0%) 100 100 100   
Male 145(98.0%) 77.2 71.0 55.6   
Age (years)b     0.019 0.889
< 60 72(48.6%) 80.6 72.2 54.9   
≥60 76(51.4%) 75 71.1 57.6   
Histological grade     2.976 0.226
Well 70(47.3%) 85.7 81.4 60.8   
Moderately 58(39.2%) 69.0 62.1 51.2   
Poorly 20(13.5%) 75.0 65.0 55.0   
Smoking indexc     3.745 0.053
< 600 67(45.3%) 83.6 77.6 66.2   
≥600 81(54.7%) 72.8 66.7 48.4   
Alcohol consumption     0.033 0.856
No 88(59.5%) 79.5 71.6 56.8   
Yes 60(40.5%) 75.0 71.7 55.6   
Primary Site     8.974 0.011*
Glottic 104(70.3%) 82.7 77.9 63.1   
Supraglottic 39(26.3%) 64.1 53.8 39.0   
Subglottic 5(3.4%) 80.0 80.0 40.0   
T Stage     6.201 0.013*
1-2 101(68.2%) 81.2 78.2 62.6   
3-4 47(31.8%) 70.2 57.4 43.5   
Cervical lymph node metastasis     21.263 < 0.001**
Negative 129(87.2%) 82.9 77.5 61.7   
Positive 19(12.8%) 42.1 31.6 21.1   
TNM Stage     7.736 0.005**
I-II 96(64.9%) 82.3 79.6 63.8   
III-IV 52(35.1%) 69.2 57.7 43.3   
Total radiation dose     1.671 0.196
< 60 Gy 61(41.2%) 78.7 75.4 62.9   
≥60 Gy 87(58.8%) 77.0 69.0 51.7   
Margin     0.395 0.530
Negative 68(45.9%) 82.4 76.5 57.9   
Positive 80(54.1%) 73.8 67.5 55.0   
TGM2     6.308 0.012*
High 70(47.3%) 72.9 64.3 45.5   
Low 78(52.7%) 82.1 78.2 65.7   
BNIP3     8.586 0.003**
High 106(71.6%) 79.2 75.5 64.4   
Low 42(28.4%) 71.4 61.9 35.7   
TGM2 & BNIP3     19.021 < 0.001**
TGM2 (-) & BNIP3 (+) 49(33.1%) 87.8 85.7 76.9   
TGM2 (+) & BNIP3 (-) 13(8.8%) 69.2 53.8 15.4   
TGM2 (+) & BNIP3 (+) 57(38.5%) 73.7 66.7 53.8   
TGM2 (-) & BNIP3 (-) 29(19.6%) 72.4 65.5 46.3   
  1. a Log-rank test. b Patients were divided into two groups according to the median age. c Smoking index is defined as the number of cigarettes used per day × the total smoking time (years). *P < 0.05, **P < 0.01