|
Features
|
No. of patients
|
TGM2
|
P
|
BNIP3
|
P
|
|---|
| | |
High
|
Low
| |
High
|
Low
| |
|---|
|
Gender
|
|
Female
|
3(2.0%)
|
0
|
3
|
0.283a
|
1
|
2
|
0.194b
|
|
Male
|
145(98.0%)
|
70
|
75
| |
105
|
40
| |
|
Age (years)c
|
|
< 60
|
72(48.6%)
|
35
|
37
|
0.755
|
52
|
20
|
0.875
|
|
≥60
|
76(51.4%)
|
35
|
41
| |
54
|
22
| |
|
Histological grade
|
|
Well
|
70(47.3%)
|
37
|
33
|
0.184
|
50
|
20
|
0.933
|
|
Moderately
|
58(39.2%)
|
22
|
36
| |
41
|
17
| |
|
Poorly
|
20(13.5%)
|
11
|
9
| |
15
|
5
| |
|
Smoking indexd
|
|
< 600
|
67(45.3%)
|
36
|
31
|
0.154
|
52
|
15
|
0.651
|
|
≥600
|
81(54.7%)
|
34
|
47
| |
54
|
27
| |
|
Alcohol consumption
|
|
No
|
88(59.5%)
|
40
|
48
|
0.587
|
56
|
32
|
0.009**
|
|
Yes
|
60(40.5%)
|
30
|
30
| |
50
|
10
| |
|
Primary Site
|
|
Glottic
|
104(70.3%)
|
50
|
54
|
0.433
|
74
|
30
|
0.791
|
|
Supraglottic
|
39(26.3%)
|
19
|
20
| |
29
|
10
| |
|
Subglottic
|
5(3.4%)
|
1
|
4
| |
3
|
2
| |
|
T Stage
|
|
1-2
|
101(68.2%)
|
47
|
54
|
0.785
|
71
|
30
|
0.600
|
|
3-4
|
47(31.8%)
|
23
|
24
| |
35
|
12
| |
|
Cervical lymph node metastasis
|
|
Positive
|
19(12.8%)
|
9
|
10
|
0.995
|
17
|
2
|
0.064
|
|
Negative
|
129(87.2%)
|
61
|
68
| |
89
|
40
| |
|
TNM Stage
|
|
I-II
|
96(64.9%)
|
46
|
50
|
0.838
|
67
|
29
|
0.502
|
|
III-IV
|
52(35.1%)
|
24
|
28
| |
39
|
13
| |
|
Total radiation dose
|
|
< 60 Gy
|
61(41.2%)
|
24
|
37
|
0.105
|
41
|
20
|
0.319
|
|
≥60 Gy
|
87(58.8%)
|
46
|
41
| |
65
|
22
| |
|
Margin
|
|
Negative
|
68(45.9%)
|
38
|
30
|
0.054
|
50
|
18
|
0.635
|
|
Positive
|
80(54.1%)
|
32
|
48
| |
56
|
24
| |
|
BNIP3
|
|
High
|
106(71.6%)
|
57
|
49
|
0.012*
| | | |
|
Low
|
42(28.4%)
|
13
|
29
| | | | |
- a Continuity correction. bFisher's exact test. c Patients were divided according to the median age. d Smoking index is defined as the number of cigarettes used per day × the total smoking time (years). *P < 0.05, **P < 0.01
