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Table 1 Expression of TGM2 and BNIP3 and their relationship with clinicopathological characteristics in laryngeal squamous cell carcinoma patients

From: Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Features No. of patients TGM2 P BNIP3 P
   High Low   High Low  
Gender
Female 3(2.0%) 0 3 0.283a 1 2 0.194b
Male 145(98.0%) 70 75   105 40  
Age (years)c
< 60 72(48.6%) 35 37 0.755 52 20 0.875
≥60 76(51.4%) 35 41   54 22  
Histological grade
Well 70(47.3%) 37 33 0.184 50 20 0.933
Moderately 58(39.2%) 22 36   41 17  
Poorly 20(13.5%) 11 9   15 5  
Smoking indexd
< 600 67(45.3%) 36 31 0.154 52 15 0.651
≥600 81(54.7%) 34 47   54 27  
Alcohol consumption
No 88(59.5%) 40 48 0.587 56 32 0.009**
Yes 60(40.5%) 30 30   50 10  
Primary Site
Glottic 104(70.3%) 50 54 0.433 74 30 0.791
Supraglottic 39(26.3%) 19 20   29 10  
Subglottic 5(3.4%) 1 4   3 2  
T Stage
1-2 101(68.2%) 47 54 0.785 71 30 0.600
3-4 47(31.8%) 23 24   35 12  
Cervical lymph node metastasis
Positive 19(12.8%) 9 10 0.995 17 2 0.064
Negative 129(87.2%) 61 68   89 40  
TNM Stage
I-II 96(64.9%) 46 50 0.838 67 29 0.502
III-IV 52(35.1%) 24 28   39 13  
Total radiation dose
< 60 Gy 61(41.2%) 24 37 0.105 41 20 0.319
≥60 Gy 87(58.8%) 46 41   65 22  
Margin
Negative 68(45.9%) 38 30 0.054 50 18 0.635
Positive 80(54.1%) 32 48   56 24  
BNIP3
High 106(71.6%) 57 49 0.012*    
Low 42(28.4%) 13 29     
  1. a Continuity correction. bFisher's exact test. c Patients were divided according to the median age. d Smoking index is defined as the number of cigarettes used per day × the total smoking time (years). *P < 0.05, **P < 0.01