Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study

Table 1 Expression of TGM2 and BNIP3 and their relationship with clinicopathological characteristics in laryngeal squamous cell carcinoma patients

Features	No. of patients	TGM2		P	BNIP3		P
		High	Low		High	Low
Gender
Female	3(2.0%)	0	3	0.283^a	1	2	0.194^b
Male	145(98.0%)	70	75		105	40
Age (years)^c
< 60	72(48.6%)	35	37	0.755	52	20	0.875
≥60	76(51.4%)	35	41		54	22
Histological grade
Well	70(47.3%)	37	33	0.184	50	20	0.933
Moderately	58(39.2%)	22	36		41	17
Poorly	20(13.5%)	11	9		15	5
Smoking index^d
< 600	67(45.3%)	36	31	0.154	52	15	0.651
≥600	81(54.7%)	34	47		54	27
Alcohol consumption
No	88(59.5%)	40	48	0.587	56	32	0.009**
Yes	60(40.5%)	30	30		50	10
Primary Site
Glottic	104(70.3%)	50	54	0.433	74	30	0.791
Supraglottic	39(26.3%)	19	20		29	10
Subglottic	5(3.4%)	1	4		3	2
T Stage
1-2	101(68.2%)	47	54	0.785	71	30	0.600
3-4	47(31.8%)	23	24		35	12
Cervical lymph node metastasis
Positive	19(12.8%)	9	10	0.995	17	2	0.064
Negative	129(87.2%)	61	68		89	40
TNM Stage
I-II	96(64.9%)	46	50	0.838	67	29	0.502
III-IV	52(35.1%)	24	28		39	13
Total radiation dose
< 60 Gy	61(41.2%)	24	37	0.105	41	20	0.319
≥60 Gy	87(58.8%)	46	41		65	22
Margin
Negative	68(45.9%)	38	30	0.054	50	18	0.635
Positive	80(54.1%)	32	48		56	24
BNIP3
High	106(71.6%)	57	49	0.012*
Low	42(28.4%)	13	29

^a Continuity correction. ^bFisher's exact test. ^c Patients were divided according to the median age. ^d Smoking index is defined as the number of cigarettes used per day × the total smoking time (years). *P < 0.05, **P < 0.01

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