Table 1 In vitro relaxation of phenylephrine-pre-contracted strips from control or diabetic rats by SAR407899, Y 27632 and sildenafil
RELAXATION OF RAT CORPUS CAVERNOSUM IC50, μM (95% confidence interval) %Emax ± SEM | ||
|---|---|---|
Controls | Diabetes | |
SAR407899 | 0.07 | 0.05 |
(0.03-0.17) | (0.03-0.10) | |
98 ± 2.1 | 97 ± 3.1 | |
Y27632 | 0.05 | 0.16 °° |
(0.02-0.09) | (0.07-0.36) | |
93 ± 1.6 | 98 ± 1.5 | |
SILDENAFIL | 0.04 | 0.17 °° |
(0.001-0.23) | (0.003-0.83) | |
95 ± 4.0 | 83 ± 4.3 | |