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Table 1 In vitro relaxation of phenylephrine-pre-contracted strips from control or diabetic rats by SAR407899, Y 27632 and sildenafil

From: Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa

  RELAXATION OF RAT CORPUS CAVERNOSUM IC50, μM (95% confidence interval) %Emax ± SEM
  Controls Diabetes
SAR407899 0.07 0.05
  (0.03-0.17) (0.03-0.10)
  98 ± 2.1 97 ± 3.1
Y27632 0.05 0.16 °°
  (0.02-0.09) (0.07-0.36)
  93 ± 1.6 98 ± 1.5
SILDENAFIL 0.04 0.17 °°
  (0.001-0.23) (0.003-0.83)
  95 ± 4.0 83 ± 4.3
  1. Maximal effect is expressed as a percentage of the relaxation induced by 0.1 mM papaverine. Results were analyzed by one-way ANOVA + Newman-Keuls test. Significance of differences between groups: p < 0.001 vs. CD control