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Table 1 PBMC treated with IFN/ribavirin.

From: Suppression of ribosomal protein synthesis and protein translation factors by Peg-interferon alpha/ribavirin in HCV patients blood mononuclear cells (PBMC)

Day 1 enrichment # of genes
Pathway SIZE FDR q-val
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 31 0.00
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 40 0.00
KEGG_PROTEASOME 41 0.02
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 70 0.02
KEGG_LYSOSOME 88 0.04
KEGG_TRYPTOPHAN_METABOLISM 17 0.04
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 21 0.06
KEGG_CITRATE_CYCLE_TCA_CYCLE 25 0.09
KEGG_CHEMOKINE_SIGNALING_PATHWAY 104 0.15
KEGG_LEISHMANIA_INFECTION 51 0.15
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 27 0.21
KEGG_APOPTOSIS 64 0.20
KEGG_PPAR_SIGNALING_PATHWAY 26 0.20
Day 1 down regulated   
KEGG_RIBOSOME 76 0.14
Day 2 enrichment   
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 40 0.00
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 31 0.00
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 69 0.00
KEGG_LYSOSOME 88 0.02
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 23 0.04
KEGG_PROTEASOME 41 0.06
KEGG_CHEMOKINE_SIGNALING_PATHWAY 103 0.08
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 95 0.12
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 37 0.15
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 27 0.15
KEGG_APOPTOSIS 65 0.19
Day 2 down regulated   
KEGG_RIBOSOME 76 0.15
Day 7 enrichment   
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 39 0.00
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 30 0.00
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 66 0.09
KEGG_APOPTOSIS 61 0.15
Day 7 down regulated   
KEGG RIBOSOME 76 0.20
Day 14 enrichment   
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 39 0.00
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 31 0.00
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 67 0.13
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 21 0.18
KEGG_PROTEASOME 41 0.22
Day 14 down regulated   
KEGG_RIBOSOME 76 0.18
Day 28 enrichment   
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 38 0.00
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 30 0.00
Day 28 down regulated   
KEGG_RIBOSOME 76 0.25
  1. 68 patients