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Table 3 Performance analysis among training and testing cohorts

From: De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer

Training Cohort (N= 32)

Predictor

 

Predicted Relapse

Predicted Non-relapse

Sensitivity

Specificity

Circulating miR-375

Observed relapse

9

1

9/10 (90%)

20/22 (91%)

 

Observed non-relapse

2

20

  

Circulating miR-122

Observed relapse

4

6

4/10 (40%)

11/22 (50%)

 

Observed non-relapse

11

11

  

375/122 two-gene signature

Observed relapse

8

2

8/10 (80%)

22/22 (100%)

 

Observed non-relapse

0

22

  

Training Cohort ( N = 26)

Predictor

 

Predicted Relapse

Predicted Non-relapse

Sensitivity

Specificity

Circulating miR-375

Observed relapse

0

8

0/8 (0%)

11/18 (61%)

 

Observed non-relapse

7

11

  

Circulating miR-122

Observed relapse

7

1

7/8 (88%)

14/18 (78%)

 

Observed non-relapse

4

14

  

375/122 two-gene signature

Observed relapse

2

6

2/8 (25%)

17/18 (94%)

 

Observed non-relapse

1

17

  
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Journal of Translational Medicine

ISSN: 1479-5876

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