Figure 1

MiRNAs detected in circulation. A. Unsupervised hierarchical clustering over all detected miRNAs. Colors in the heatmap represent a sample's higher (red) or lower (green) level in relation to the mean of all samples. The status of each clinical parameter was represented by colored boxes as indicated in the figure. B. The top 100 miRNAs with the highest quantities in circulation. For each miRNA shown, the range of normalized counts was indicated by a column, and the mean value was indicated by a line. Arrows indicate the positions of miR-122 and miR-375 in the order of abundance.