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Table 3 Cox Regression analysis of the SPARC expression, clinicopathological variables for overall survival in NPC patients

From: Secreted protein acidic and rich in cysteine (SPARC) is associated with nasopharyngeal carcinoma metastasis and poor prognosis

Variable Univariate Crude HR (95% CI) P value *Multivariate adjusted HR (95% CI) P value
SPARC expression     
High versus Low 1.785 (1.455-2.190) < 0.001 1.741 (1.414-2.144) < 0.001
Agec (years)     
> 47 versus ≤ 47 1.554 (1.265-1.910) < 0.001 1.551 (1.259-1.910) < 0.001
Sex     
Female versus Male 0.780 (0.616-0.987) 0.039 0.854 (0.673-1.083) 0.193
Clinical Stage     
III + IV versus I + II 4.692 (3.325-6.620) < 0.001 4.766 (3.361-6.758) < 0.001
WHO histological classification     
NKDC versus NKUC 0.935 (0.716-1.222) 0.625 0.919 (0.701-1.205) 0.54
KSCC versus NKUC 1.988 (1.183-3.342) 0.01 1.804 (1.069-3.047) 0.027
  1. *Adjusted for SPARC expression, sex, WHO histological classification, age, and clinical stage. SPARC secreted protein acidic and rich in cysteine; WHO World health organization; NPC nasopharyngeal carcinoma; NKUC, non-keratinizing undifferentiated carcinoma; NKDC non-keratinizing differentiated carcinoma; KSCC keratinizing squamous cell carcinoma; HR hazard ratio; CI confidence interval