|
Variable
|
Univariate Crude HR (95% CI)
|
P value
|
*Multivariate adjusted HR (95% CI)
|
P value
|
|---|
|
SPARC expression
| | | | |
|
High versus Low
|
1.785 (1.455-2.190)
|
< 0.001
|
1.741 (1.414-2.144)
|
< 0.001
|
|
Agec (years)
| | | | |
|
> 47 versus ≤ 47
|
1.554 (1.265-1.910)
|
< 0.001
|
1.551 (1.259-1.910)
|
< 0.001
|
|
Sex
| | | | |
|
Female versus Male
|
0.780 (0.616-0.987)
|
0.039
|
0.854 (0.673-1.083)
|
0.193
|
|
Clinical Stage
| | | | |
|
III + IV versus I + II
|
4.692 (3.325-6.620)
|
< 0.001
|
4.766 (3.361-6.758)
|
< 0.001
|
|
WHO histological classification
| | | | |
|
NKDC versus NKUC
|
0.935 (0.716-1.222)
|
0.625
|
0.919 (0.701-1.205)
|
0.54
|
|
KSCC versus NKUC
|
1.988 (1.183-3.342)
|
0.01
|
1.804 (1.069-3.047)
|
0.027
|
- *Adjusted for SPARC expression, sex, WHO histological classification, age, and clinical stage. SPARC secreted protein acidic and rich in cysteine; WHO World health organization; NPC nasopharyngeal carcinoma; NKUC, non-keratinizing undifferentiated carcinoma; NKDC non-keratinizing differentiated carcinoma; KSCC keratinizing squamous cell carcinoma; HR hazard ratio; CI confidence interval
