Figure 1

Rat survival 72 h after cecal ligation and puncture ( CLP ) or sham procedure ( SP ). A) By 72 h after the CLP procedure, the survival rate of groups CLP and CLP + H-ADMSC were significantly lower than in groups SP and CLP + A-ADMSC (all p values < 0.05) but it showed no difference between groups CLP and CLP + H-ADMSC (p = p = 0.289) or between groups SP and CLP + A-ADMSC (p = 1.0). * vs. other bars with different symbols, p < 0.001. All statistical analyses performed using one-way ANOVA followed by Bonferroni multiple comparison post hoc test. Symbols (*, †) indicating statistical significance (at 0.05 level). B) Kaplan-Meyer analysis comparing survival amongst the four groups, demonstrating that 72 h cumulative mortality was significantly higher in the CLP + H-ADMSC group and untreated CLP group than in SP controls and A-ADMSC group (p < 0.001). There were no significant survival differences between groups SP and CLP + A-ADMSC (p = 1.0), or between groups CLP and CLP + H-ADMSC (p = 0.289). H-ADMSCs = healthy adipose-derived mesenchymal stem cells; A-ADMSCs = apoptotic adipose-derived mesenchymal stem cells.