Figure 3

MicroRNAs regulate cell metabolism by targeting key metabolic enzymes and multiple oncogenic signaling pathways. MiRNAs could regulate cell metabolism by modulating the expression of metabolic transporters (like GLUT) or enzymes (HK2, ALDOA and PDK1) and acting on p53, c-Myc and AKT/mTOR signaling pathways. The steps regulated by miRNAs are indicated by red circular arrows, and the related miRNAs are listed in the bracket. FASN, fatty acid synthase; GLUT, glucose transporter; HIF, hypoxia-inducible factor; LAT1, L-type amino acid transporter 1; LDH-A, lactate dehydrogenase isoform A; MCT, monocarboxylate transporter; PDH, pyruvate dehydrogenase; PDK, pyruvate dehydrogenase kinase; PI3K, phosphatidylinositol 3-kinase.