Skip to main content

Table 3 The levels of cytokines in whole blood culture supernatants in MS patients

From: A gender-related action of IFNbeta-therapy was found in multiple sclerosis

  Treated Patients Untreated Patients
Cytokines(pg/ml) Basic condition Basic condition
  Men Women Men Women
IL10 2.13 ± 0.4 1.8 ± 0.2 1.5 ± 0.1 1.8 ± 0.2
IFNγ 16.1 ± 5 11.4 ± 3.2 14 ± 2.3 19.8 ± 3.6
IL6 232 ± 227a 10 ± 9.8a 35.8 ± 11.5 12.0 ± 17.5
IL2 10.8 ± 1 8.7 ± 0.9 8.7 ± 3.5 9.4 ± 1.5
IL4 1.1 ± 0.2 1.1 ± 0.1 0.7 ± 0.1 0.7 ± 0.1
IL12p70 9.2 ± 0.9 9.5 ± 0.8 11.2 ± 1.2 8.4 ± 0.7
IL12p40 25.2 ± 2.6 21.6 ± 3 20.1 ± 6.5 20.7 ± 5.1
TGFβ 7324 ± 833 5903 ± 458 10721 ± 5822 5758 ± 386
  PHA PHA
  Men Women Men Women
IL10 59.7 ± 24.9 23.7 ± 11.8 78 ± 17.4 49.4 ± 30.2
IFNγ 1149.2 ± 570 740 ± 112.9b 2238 ± 904 2102 ± 658b
IL6 759 ± 359 627 ± 109.1 673 ± 427 648.1 ± 153.8
IL2 18.3 ± 5.9 13.9 ± 7.4 20.6 ± 8 21.3 ± 4.1
IL4 9.7 ± 5.3 3.6 ± 1.3 3.6 ± 1.1 1.2 ± 1.5
IL12p70 13.4 ± 2.5 9.9 ± 0.6 9.1 ± 1.5 9.3 ± 0.9
IL12p40 196 ± 105 101.7 ± 15.4 186 ± 82 86.2 ± 15.4
TGFβ 7644 ± 906 6953 ± 583 16029 ± 8457 8612 ± 4630.1
  LPS LPS
  Men Women Men Women
IL10 144 ± 28.2 215 ± 54.7 181 ± 50 195.5 ± 48.6
IFNγ 135 ± 37.9 71.2 ± 139.4 1131 ± 809.3 263 ± 88.5
IL6 989 ± 89 635.9 ± 112.5 795 ± 173 813.2 ± 123.7
IL2 15.6 ± 3.7c 11 ± 4.4 7.6 ± 1.5c 12 ± 1.6
IL4 1.54 ± 0.5 1.1 ± 0.1d 0.7 ± 0.1 0.7 ± 0.06d
IL12p70 11.5 ± 1.9 8.9 ± 0.8 9.7 ± 0.9 9.1 ± 0.7
IL12p40 416 ± 309 354.4 ± 69.5 1203 ± 664 284.2 ± 87.2
TGFβ 7582 ± 832 7524.6 ± 3492.7e 12669 ± 6570 16984 ± 4854.8e
  1. Levels were determined by whole blood assays in resting conditions (Basic conditions) and after stimulation with PHA (to principally study the activated T cell network contribution) and LPS (to evaluate the influence of activated antigen presenting cells). The level values are expressed as mean ± SD and statistical differences between groups were assessed using the Mann–Whitney U-test or Student’s t-test as appropriate: aa p = 0.027; bb p = 0.023; cc p = 0.039; dd p = 0.002; ee p = 0.031.