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Table 2 The levels of cytokines in culture supernatants of IDC and DC in MS patients

From: A gender-related action of IFNbeta-therapy was found in multiple sclerosis

Cytokines(pg/ml∘U/ml

Treated patients

IDC

IDC-LPS

Man

Women

Man

Women

IL10

5.3 ± 0.1a

3.3 ± 0.9

73.9 ± 37.5

41.2 ± 7.9

IL12p70

0 ± 0.02

0.13 ± 0.13b

3.3 ± 3.1

4.5 ± 1.3i

IL12p40

58.2 ± 11.4

35.8 ± 5.9d

3834 ± 796l

3863 ± 260m

TGFβ

22156 ± 1091e

21792 ± 701f

20701 ± 1103n

20164 ± 633p

∘sCD30

7.01 ± 0.4g

6.9 ± 1.1h

13.5 ± 1.1q

14.7 ± 1.1r

Cytokines(pg/ml ∘ U/ml

Untreated patients

IDC

IDC-LPS

Man

Women

Man

Women

IL10

0.6 ± 0.6a

1.1 ± 0.5

27.5 ± 19.2

55.8 ± 13.1

IL12p70

0.37 ± 0.9c

2.9 ± 0.6b,c

9.7q ± 6.5

17.1 ± 3.8i

IL12p40

51.9 ± 6.8

63.7 ± 7.3d

5999 ± 277l

5094 ± 647m

TGFβ

16582 ± 813e

16400 ± 575f

14726 ± 642n

14210 ± 601p

∘sCD30

27.2 ± 24g

26.8 ± 5h

36.9 ± 3.2q

38.1 ± 3.5r

  1. Cytokine levels were determined in culture supernatants of IDC (to evaluate the APC influence on immune response in resting conditions) and of DC (to evaluate the APC influence on immune response in activation conditions). The levels are expressed as mean (or median) ± standard error, as appropriate. Statistical differences between groups were determined using the Mann–Whitney U-test or Student’s t-test as appropriate: aa p = 0.008; bb p < 0.0001; cc p = 0.03; dd p = 0.006; ee p = 0.004; ff p < 0.0001; gg p = 0.0007; hh p < 0.0001; ii p = 0.001; ll p = 0.013; mm p = 0.006; nn p = 0.001; pp p = 0.001; qq p = 0.001; rr p = 0.001.
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Journal of Translational Medicine

ISSN: 1479-5876

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