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Table 2 The levels of cytokines in culture supernatants of IDC and DC in MS patients

From: A gender-related action of IFNbeta-therapy was found in multiple sclerosis

Cytokines(pg/mlU/ml Treated patients
IDC IDC-LPS
Man Women Man Women
IL10 5.3 ± 0.1a 3.3 ± 0.9 73.9 ± 37.5 41.2 ± 7.9
IL12p70 0 ± 0.02 0.13 ± 0.13b 3.3 ± 3.1 4.5 ± 1.3i
IL12p40 58.2 ± 11.4 35.8 ± 5.9d 3834 ± 796l 3863 ± 260m
TGFβ 22156 ± 1091e 21792 ± 701f 20701 ± 1103n 20164 ± 633p
sCD30 7.01 ± 0.4g 6.9 ± 1.1h 13.5 ± 1.1q 14.7 ± 1.1r
Cytokines(pg/ml U/ml Untreated patients
IDC IDC-LPS
Man Women Man Women
IL10 0.6 ± 0.6a 1.1 ± 0.5 27.5 ± 19.2 55.8 ± 13.1
IL12p70 0.37 ± 0.9c 2.9 ± 0.6b,c 9.7q ± 6.5 17.1 ± 3.8i
IL12p40 51.9 ± 6.8 63.7 ± 7.3d 5999 ± 277l 5094 ± 647m
TGFβ 16582 ± 813e 16400 ± 575f 14726 ± 642n 14210 ± 601p
sCD30 27.2 ± 24g 26.8 ± 5h 36.9 ± 3.2q 38.1 ± 3.5r
  1. Cytokine levels were determined in culture supernatants of IDC (to evaluate the APC influence on immune response in resting conditions) and of DC (to evaluate the APC influence on immune response in activation conditions). The levels are expressed as mean (or median) ± standard error, as appropriate. Statistical differences between groups were determined using the Mann–Whitney U-test or Student’s t-test as appropriate: aa p = 0.008; bb p < 0.0001; cc p = 0.03; dd p = 0.006; ee p = 0.004; ff p < 0.0001; gg p = 0.0007; hh p < 0.0001; ii p = 0.001; ll p = 0.013; mm p = 0.006; nn p = 0.001; pp p = 0.001; qq p = 0.001; rr p = 0.001.