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Table 1 The levels of the different types of specific cytokines in healthy subjects

From: A gender-related action of IFNbeta-therapy was found in multiple sclerosis

Whole blood and PBMC supernatants
Healthy subjects
Men
Basic condition PHA LPS
pg/ml Meanwb± SD Means± SD Meanwb± SD Means± SD Meanwb± SD
IL10 4,9 ± 13,4 26 ± 40,2 37,6 ± 43,2 93,7 ± 116,7 61,1 ± 96,4
IFNγ 149 ± 194,3 161,8 ± 146,2 1752 ± 2344,5 415,7 ± 389,3 1473,2 ± 2408
IL6 133,3 ± 376,2 390,7 ± 495,7 235,7 ± 303,2 1386,3 ± 2138,3 573,5 ± 714,9
IL2 256 ± 181.8 64,1 ± 78,2 248,7 ± 233,4 290,4 ± 196,8  
IL4 15,5 ± 32,2 7,4 ± 10,4 21,9 ± 29 21,8 ± 24,4  
Women
Basic condition PHA LPS
pg/ml Mean wb ± SD Mean s ± SD Mean wb ± SD Mean s ± SD Mean wb ± SD
IL10 26 ± 46,3 155 ± 180,8 6,9 ± 8,8 143 ± 155,4 72,9 ± 150,3
IFNγ 70,1 ± 110 173,2 ± 74,4 1300,3 ± 2294 1071,1 ± 1102,2 1603 ± 4603
IL6 34,8 ± 67,9 243,3 ± 293,4 104,4 ± 156 1921,5 ± 1654 316,7 ± 322,6
IL2 153,6 ± 140 238,8 ± 247,1 222,4 ± 193 573,4 ± 438,1  
IL4 29,4 ± 47,7 24,3 ± 36,6 76,6 ± 115,7 9,7 ± 4,7  
  1. Cytokine levels were determined in whole blood (wb) and PBMC supernatant (s) in resting (Basic conditions) and activation conditions after stimulation with PHA (to study T cell network contribution) and LPS (to evaluate the influence of antigen presenting cells). The levels are expressed as mean ± SD, and statistical differences between men and women were assessed using the Mann–Whitney U-test or Student’s t-test as appropriate. Production levels of cytokines did not differ significantly with the exception of IL10 (using the wb method) which was higher in men than in women when PHA stimulus was used (p = 0.038).