Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation

Table 4 Subject characteristics and PLAUR and ChAt analysis in validation study

						PLAUR correlation with whole brain volume			ChAt correlation with whole brain volume
	N	Gender (% F)	Age mean (SD)	MMSE* mean (SD)	PLAUR mean (SD) **	R	p	ChAt mean (SD) **	R	p
Controls	82	58	72.8 (7.0)	29 (1.1)	1.63 (0.9)	−0.35	<0.005	0.78 (0.3)	0.34	<0.01
MCI	80	57	74.7 (6.2)	27 (2.2)	0.98 (0.7)	0.14	NS	0.75 (0.3)	0.01	NS
AD	78	69	76.2 (6.4)	21 (4.5)	0.85 (0.3)	−0.2	NS	0.71 (0.3)	0.23	0.06

*MMSE; Mini mental state examination - a cognitive scale (maximum score = 30) used to screen for and assess degree of severity of dementia. A score of less than 24 indicates possible dementia. A score of 10–20 suggests moderate dementia and a score above 20, mild dementia. ** arbitrary units.

ISSN: 1479-5876