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Table 3 Univariate Cox regression models for TOP2A expression according to HER2 status

From: Topoisomerase II alpha gene amplification is a favorable prognostic factor in patients with HER2-positive metastatic breast cancer treated with trastuzumab

 

HER2-positive

HER2-negative

Events

HR

95% CI

Wald’s p

Events

HR

95% CI

Wald’s p

TTP

        

TOP2A (FISH)

        

Deleted vs. Amplified

16 vs. 36

1.58

0.87-2.87

0.13

    

Non-amplified vs. Amplified

43 vs. 36

1.51

0.96-2.37

0.07

    

TopoIIa (IHC)

        

Positive vs. Negative

57 vs. 27

0.94

0.60-1.49

0.80

31 vs. 17

1.01

0.55-1.83

0.98

Survival

        

TOP2A (FISH)

        

Deleted vs. Amplified

12 vs. 17

2.67

1.27-5.62

0.009

    

Non-amplified vs. Amplified

33 vs. 17

2.16

1.20-3.88

0.010

    

TopoIIa (IHC)

        

Positive vs. Negative

38 vs. 19

0.71

0.41-1.24

0.22

23 vs. 14

0.70

0.36-1.37

0.30

  1. CI confidence interval, HR hazard ratio, TTP time to progression.
  2. Empty cells: Non-applicable.
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Journal of Translational Medicine

ISSN: 1479-5876

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