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Table 4 Association of CDKN2A methylation and clinico-pathological features stratified by microsatellite instability (MSI) status

From: Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing

Feature   CDKN2A in MSS/MSI-L (n;%) P-value CDKN2A in MSI-H (n;%) P-value
   Negative Positive   Negative Positive  
   (n = 272; 81.4%) (n = 62; 18.6%)   (n = 42; 68.9%) (n = 19; 31.2%)  
Age Mean (range) 69.5 (40–95) 69.9 (44–88) 0.788 68.4 (45–87) 68.2 (50–89) 0.9897
Tumor size Mean (range) 48.0 (5–130) 49.8 (4–105) 0.523 54.9 (19–160) 62.8 (15–170) 0.3737
Tumor location Left-sided 193 (71.2) 34 (54.8) 0.0125 24 (57.1) 4 (22.2) 0.013
  Right-sided 78 (28.8) 28 (45.2)   18 (42.9) 14 (77.8)  
Gender Female 149 (54.8) 34 (54.8) 0.9932 20 (47.6) 10 (52.6) 0.7169
  Male 123 (45.2) 28 (45.2)   22 (52.4) 9 (47.4)  
Histological subtype Non-mucinous 253 (93.0) 54 (87.1) 0.1142 39 (92.9) 16 (84.2) 0.2863
  Mucinous 16 (5.9) 8 (12.9)   3 (7.1) 2 (10.5)  
Tumor grade G1-2 261 (98.1) 54 (87.1) <0.0001 37 (88.1) 14 (73.7) 0.2608
  G3 5 (1.9) 8 (12.9)   5 (11.9) 5 (26.3)  
pT classification pT1-2 59 (22.1) 13 (21.0) 0.8354 12 (28.6) 0 (0.0) 0.0093
  pT3-4 207 (77.8) 49 (79.0)   30 (71.4) 19 (100.0)  
pN classification pN0 140 (53.4) 23 (37.1) 0.0207 26 (66.7) 10 (52.6) 0.3012
  pN1-2 122 (46.6) 39 (62.9)   13 (33.3) 9 (47.4)  
Vascular invasion Absent 186 (69.9) 37 (59.7) 0.1193 35 (83.3) 11 (57.9) 0.0326
  Present 80 (30.1) 25 (40.3)   7 (16.7) 8 (42.1)  
Invasive margin Pushing 69 (26.0) 12 (19.7) 0.2996 26 (61.9) 6 (31.6) 0.0281
  Infiltrating 196 (74.0) 49 (80.3)   16 (38.1) 13 (68.4)  
Peritumoral lymphocytic inflammation Absent 211 (79.3) 51 (82.3) 0.6037 27 (64.3) 13 (68.4) 0.7529
  Present 55 (20.7) 11 (17.7)   15 (35.7) 6 (31.6)  
KRAS (codon 12/13) Wild-type 185 (69.0) 41 (68.3) 0.9161 26 (65.0) 14 (93.3) 0.0356
  Mutation 83 (31.0) 19 (31.7)   14 (35.0) 1 (6.7)  
BRAF (codon V600E) Wild-type 245 (96.8) 42 (75.0) <0.0001 30 (79.0) 8 (44.4) 0.0098
  Mutation 8 (3.2) 14 (25.0)   8 (21.0) 10 (55.6)