Figure 5

GLV-1h68 strain preferentially replicates in ALDEFLUOR-positive cell population of GI-101A and enhanced replication in the tumors derived from ALDEFLUOR-positive cells. Preferential replication of GLV-1h68 strain at (A) MOI0.01 and (B) MOI10 in ALDEFLUOR-positive cell population of GI-101A breast cancer cells followed by viral titration in CV-1 cells. (C) Enhanced fluorescent GFP protein expression in ALDEFLUOR-positive cells derived tumor in comparison to ALDEFLUOR-negative cells. (D) Enhanced inhibition of tumor growth in ALDEFLUOR-positive cells derived tumors in comparison to ALDEFLUOR-negative cells derived tumors.