Figure 2

Histological scores of kidney by 24-week after CKD induction. H & E staining [200 x (A to E) & 400x (G to K)] of kidney sections in groups 1 to 5 animals (A to K) showing notably higher degree of loss of brush border in renal tubules (yellow arrowheads), cast formation (blue asterisk), tubular dilatation (blue arrows), tubular necrosis (green arrows), and less intact of renal tubule (yellow arrows) in group 3. Further enhanced damage in group 4 compared with that in groups 1 and 2, but notably improved in group 5 after rosuvastatin treatment. Also note crystal formations (green asterisk) in groups 3 and 4 animals. F) * vs. other groups, p < 0.0001 (by one-way ANOVA). Symbols (*, †, ‡, §, ¶) indicate significance (at 0.05 level by Bonferroni multiple comparison post hoc test) (n = 10 in each group). Scale bars in right lower corner represent 50 μm in A-E and 20 μm in G-K.